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Does Voriconazole Interact with Rifampin?

Voriconazole and Rifampin have a contraindicated drug interaction according to U.S. FDA drug labeling data. CYP450 inducer significantly reduces voriconazole plasma exposure. The mechanism involves cyp450 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Voriconazole Class
Azole Antifungal
Rifampin Class
Rifamycin Antibacterial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Voriconazole and Rifampin occurs because cyp450 induction. Clinically, this means cyp450 inducer significantly reduces voriconazole plasma exposure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Voriconazole and your doctor is considering prescribing Rifampin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Voriconazole(Vfend)+💊 Rifampin(Rifadin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Azole Antifungal
Drug B class
Rifamycin Antibacterial
Source
NLP:voriconazole

What this means in plain English

CYP450 inducer significantly reduces voriconazole plasma exposure.

About Voriconazole and Rifampin

Voriconazole is an Azole Antifungal, while Rifampin is a Rifamycin Antibacterial. You may recognize them by the brand names Vfend and Rifadin. Both medications are taken by mouth.

What the FDA label says

"CYP450 Induction"

📖 Source: NLP:voriconazole

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.