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Does Warfarin Interact with Bumetanide?

Warfarin and Bumetanide have a minor drug interaction according to U.S. FDA drug labeling data. Interaction studies in humans have shown bumetanide has no effect on warfarin metabolism or plasma prothrombin activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Bumetanide Class
Loop Diuretic
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Warfarin and your doctor is considering prescribing Bumetanide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Warfarin(Warfarin Sodium)+💊 Bumetanide(Bumex)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Loop Diuretic
Source
NLP:bumetanide

What this means in plain English

Interaction studies in humans have shown bumetanide has no effect on warfarin metabolism or plasma prothrombin activity.

About Warfarin and Bumetanide

Bumetanide is a Loop Diuretic. Bumetanide is also sold under the brand name Bumex. Both medications are taken by mouth. Both Warfarin and Bumetanide carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.