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Does Warfarin Interact with Duloxetine?

Warfarin and Duloxetine have a moderate drug interaction according to U.S. FDA drug labeling data. Monitor carefully when initiating or discontinuing duloxetine. Altered anticoagulant effects and increased bleeding reported with SNRIs; however, duloxetine did not significantly affect INR or warfarin pharmacokinetics in clinical study. The mechanism involves platelet dysfunction and potential serotonergic effects on hemostasis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Warfarin and Duloxetine occurs because platelet dysfunction and potential serotonergic effects on hemostasis. Clinically, this means monitor carefully when initiating or discontinuing duloxetine. altered anticoagulant effects and increased bleeding reported with snris; however, duloxetine did not significantly affect inr or warfarin pharmacokinetics in clinical study. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Warfarin and your doctor is considering prescribing Duloxetine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Warfarin(Warfarin Sodium)+💊 Duloxetine(Irenka)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:duloxetine

What this means in plain English

Monitor carefully when initiating or discontinuing duloxetine. Altered anticoagulant effects and increased bleeding reported with SNRIs; however, duloxetine did not significantly affect INR or warfarin pharmacokinetics in clinical study.

About Warfarin and Duloxetine

Duloxetine is also sold under the brand name Irenka. Both medications are taken by mouth. Both Warfarin and Duloxetine carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"Platelet dysfunction and potential serotonergic effects on hemostasis"

📖 Source: NLP:duloxetine

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.