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Does Warfarin Interact with Nitazoxanide?

Warfarin and Nitazoxanide have a moderate drug interaction according to U.S. FDA drug labeling data. Competition for plasma protein binding sites may occur when nitazoxanide is administered concurrently with warfarin. Monitor for adverse reactions due to potential displacement from binding sites. The mechanism involves competition for plasma protein binding sites; tizoxanide (active metabolite) is >99.9% protein bound. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Nitazoxanide Class
Antiprotozoal
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Warfarin and Nitazoxanide occurs because competition for plasma protein binding sites; tizoxanide (active metabolite) is >99.9% protein bound. Clinically, this means competition for plasma protein binding sites may occur when nitazoxanide is administered concurrently with warfarin. monitor for adverse reactions due to potential displacement from binding sites. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Warfarin and your doctor is considering prescribing Nitazoxanide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Warfarin(Warfarin Sodium)+💊 Nitazoxanide(Nitazoxanide)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Antiprotozoal
Source
NLP:nitazoxanide

What this means in plain English

Competition for plasma protein binding sites may occur when nitazoxanide is administered concurrently with warfarin. Monitor for adverse reactions due to potential displacement from binding sites.

What the FDA label says

"Competition for plasma protein binding sites; tizoxanide (active metabolite) is >99.9% protein bound"

📖 Source: NLP:nitazoxanide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.