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Does Warfarin Interact with Rivaroxaban?

Warfarin and Rivaroxaban have a contraindicated drug interaction according to U.S. FDA drug labeling data. Anticoagulant. Avoid concurrent use due to increased bleeding risk unless benefit outweighs risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Contraindicated
Rivaroxaban Class: Factor Xa Inhibitor
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Warfarin and your doctor is considering prescribing Rivaroxaban (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Warfarin(Warfarin Sodium)+💊 Rivaroxaban(Xarelto)

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

Factor Xa Inhibitor

Source

NLP:rivaroxaban

What this means in plain English

Anticoagulant. Avoid concurrent use due to increased bleeding risk unless benefit outweighs risk.

About Warfarin and Rivaroxaban

Rivaroxaban is a Factor Xa Inhibitor. Rivaroxaban is also sold under the brand name Xarelto. Both medications are taken by mouth. Both Warfarin and Rivaroxaban carry an FDA boxed warning — the agency's most serious safety designation.

Recent research & FDA safety updates

Live

Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Warfarin Sodium Tablets, USP, 5 mg, 100 Tablets per bottle, Rx Only, Manufactured for: Teva Pharmaceabout Warfarin · 2024-01

FDA

FDA Safety Alert: Rivaroxaban active pharmaceutical ingredient packaged in varying grams or kg in bags or drums, Attixabout Rivaroxaban · 2015-04

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.