apomorphine and metoclopramide: what the product label says

The product label for apomorphine names metoclopramide in its drug-interaction information. The complete selected section is reproduced below so that qualifications stay with the finding.

Which products this evidence covers

ONAPGO — INJECTION, SOLUTION — SUBCUTANEOUS

Labeled active ingredients: APOMORPHINE HYDROCHLORIDE; APOMORPHINE. Routes: SUBCUTANEOUS. Dosage forms: INJECTION, SOLUTION.

Supporting label passage

Section: 7.4 Dopamine Antagonists

Because ONAPGO is a dopamine agonist, it is possible that concomitant use of dopamine antagonists, such as the neuroleptics (phenothiazines, butyrophenones, thioxanthenes) or metoclopramide, may diminish the effectiveness of ONAPGO. Antiemetics with anti-dopaminergic actions should be avoided [see Warnings and Precautions (5.2) ]. Patients with major psychotic disorders, treated with neuroleptics, should be treated with dopamine agonists only if the potential benefits outweigh the risks [see Warnings and Precautions (5.7) ].

Read the full product label on DailyMed. Label version 21, dated 2026-10-05.

Limits of this evidence

This passage applies to the labeled product and circumstances it describes. It must not be generalized to other routes or formulations. It does not independently validate CDI’s severity category, establish safety for an individual, or replace the full label. The stored interaction description and classification have not been changed by this article.

How this brief was prepared

Automatic checks matched drug identities, retrieved and preserved the label, and checked the full quoted section with AI assistance on 2026-11-06. The public explanation uses a fixed template; model-written medical advice is not published. Independent clinical review has not been recorded.

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