Home›Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate

Also known as: Mb Caps

Route: Oral

Check Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate Interactions →

21 interactions on record

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate has 21 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetazolamide, Fluoxetine, Alfentanil. Patients taking Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 21
Major: 2
Moderate: 19

Major (2)

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Acetazolamide— May precipitate with formaldehyde in urine, increasing the danger of crystalluria.
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Fluoxetine— Methylene blue can cause serotonin syndrome; fluoxetine must be stopped at least 5 weeks before methylene blue treatment…

Moderate (19)

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Alfentanil— Methylene blue inhibits CYP3A4/5 metabolism. Alfentanil has narrow therapeutic index; clinical relevance unknown but con…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Andthiazide— May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Antacids Containing Calcium— May reduce absorption of hyoscyamine and cause urine alkalinity, reducing methenamine effectiveness. Doses should be spa…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Antiperistaltic Antidiarrheal Drugs— May reduce absorption of hyoscyamine resulting in decreased therapeutic effectiveness. Doses should be spaced 1 hour apa…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Cyclosporine— Methylene blue inhibits CYP3A4/5 metabolism. Cyclosporine has narrow therapeutic index; clinical relevance unknown but c…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Digoxin— Methylene blue inhibits CYP3A4/5 metabolism. Digoxin has narrow therapeutic index; clinical relevance unknown but concur…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Dihydroergotamine— Methylene blue inhibits CYP3A4/5 metabolism. Dihydroergotamine has narrow therapeutic index; clinical relevance unknown …
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Ergotamine— Methylene blue inhibits CYP3A4/5 metabolism. Ergotamine has narrow therapeutic index; clinical relevance unknown but con…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Fentanyl— Methylene blue inhibits CYP3A4/5 metabolism. Fentanyl has narrow therapeutic index; clinical relevance unknown but concu…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Ketoconazole— May cause increased gastrointestinal pH resulting in marked reduction in ketoconazole absorption. Take combination at le…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Monoamine Oxidase Inhibitors (Maois)— Concurrent use with hyoscyamine may intensify antimuscarinic side effects.
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Opioid Analgesics— May result in increased risk of severe constipation.
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Phenytoin— Methylene blue inhibits CYP2C9 and CYP2C19 metabolism. Phenytoin has narrow therapeutic index; clinical relevance unknow…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Pimozide— Methylene blue inhibits CYP3A4/5 and CYP1A2 metabolism. Pimozide has narrow therapeutic index; clinical relevance unknow…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Quinidine— Methylene blue inhibits CYP2D6 metabolism. Quinidine has narrow therapeutic index; clinical relevance unknown but concur…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Rapamycin— Methylene blue inhibits CYP3A4/5 metabolism. Sirolimus has narrow therapeutic index; clinical relevance unknown but conc…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Tacrolimus— Methylene blue inhibits CYP3A4/5 metabolism. Tacrolimus has narrow therapeutic index; clinical relevance unknown but con…
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Urinary Alkalinizing Agents— May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.
Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Warfarin— Methylene blue inhibits CYP2C9 metabolism. Warfarin has narrow therapeutic index; clinical relevance unknown but concurr…

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Acetazolamide⚠️Major

May precipitate with formaldehyde in urine, increasing the danger of crystalluria.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Fluoxetine⚠️Major

Methylene blue can cause serotonin syndrome; fluoxetine must be stopped at least 5 weeks before methylene blue treatment due to its longer half-life.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Alfentanil🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Alfentanil has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Andthiazide🟡Moderate

May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Antacids Containing Calcium🟡Moderate

May reduce absorption of hyoscyamine and cause urine alkalinity, reducing methenamine effectiveness. Doses should be spaced 1 hour apart.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Antiperistaltic Antidiarrheal Drugs🟡Moderate

May reduce absorption of hyoscyamine resulting in decreased therapeutic effectiveness. Doses should be spaced 1 hour apart.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Cyclosporine🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Cyclosporine has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Digoxin🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Digoxin has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Dihydroergotamine🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Dihydroergotamine has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Ergotamine🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Ergotamine has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Fentanyl🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Fentanyl has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Ketoconazole🟡Moderate

May cause increased gastrointestinal pH resulting in marked reduction in ketoconazole absorption. Take combination at least 2 hours after ketoconazole.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Monoamine Oxidase Inhibitors (Maois)🟡Moderate

Concurrent use with hyoscyamine may intensify antimuscarinic side effects.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Opioid Analgesics🟡Moderate

May result in increased risk of severe constipation.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Phenytoin🟡Moderate

Methylene blue inhibits CYP2C9 and CYP2C19 metabolism. Phenytoin has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Pimozide🟡Moderate

Methylene blue inhibits CYP3A4/5 and CYP1A2 metabolism. Pimozide has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Quinidine🟡Moderate

Methylene blue inhibits CYP2D6 metabolism. Quinidine has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Rapamycin🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Sirolimus has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Tacrolimus🟡Moderate

Methylene blue inhibits CYP3A4/5 metabolism. Tacrolimus has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Urinary Alkalinizing Agents🟡Moderate

May cause urine to become alkaline, reducing effectiveness of methenamine by inhibiting its conversion to formaldehyde.

Methenamine, Sodium Phosphate, Monobasic, Monohydrate, Phenyl Salicylate, Methylene Blue, And Hyoscyamine Sulfate + Warfarin🟡Moderate

Methylene blue inhibits CYP2C9 metabolism. Warfarin has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.