Does Methenamine Sodium Phosphate Monobasic Monohydrate Phenyl Sa Interact with Cyclosporine?
CDI records a moderate classification for Methenamine Sodium Phosphate Monobasic Monohydrate Phenyl Sa and Cyclosporine. The stored summary is: Methylene blue inhibits CYP3A4/5 metabolism. Cyclosporine has narrow therapeutic index; clinical relevance unknown but concurrent use requires caution. The mechanism involves cyp3a4/5 inhibition by methylene blue. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A4/5 inhibition by methylene blue
What To Tell Your Doctor or Pharmacist
If you are taking Methenamine Sodium Phosphate Monobasic Monohydrate Phenyl Sa and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider