Succinylcholine

Cyclophosphamide causes marked and persistent inhibition of cholinesterase activity. Prolonged apnea may occur with concurrent depolarizing muscle relaxants within 10 days of treatment.

Cyclophosphamide causes marked and persistent inhibition of cholinesterase activity; prolonged apnea may occur with depolarizing muscle relaxants within 10 days of cyclophosphamide treatment.

Neostigmine use to reverse depolarizing muscle relaxants like succinylcholine is not recommended because it may prolong the phase-1 block.

Contraindicated in intoxication with depolarizing muscle relaxants of the suxamethonium type.

Prior administration quickens onset and may increase depth of neuromuscular block. Atracurium should not be administered until patient recovers from succinylcholine-induced block.

Synergistic effect expected when given concurrently with galantamine, a cholinesterase inhibitor.

Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.

Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.

May cause sudden extrusion of potassium from muscle cells and arrhythmias in digitalized patients.

Synergistic effect may be expected with concomitant administration of succinylcholine due to cholinesterase inhibition.

Echothiophate iodide potentiates succinylcholine, a cholinesterase inhibitor, leading to possible additive effects.

Esmolol prolongs the duration of succinylcholine-induced neuromuscular blockade.

Synergistic effect expected when given concurrently with galantamine, a cholinesterase inhibitor.

Synergistic effect expected when given concurrently with galantamine. May result in increased neuromuscular blocking effects.

Neuromuscular blockade and respiratory paralysis possible. Use with caution in patients receiving aminoglycosides by any route.

Gepotidacin, as an acetylcholinesterase inhibitor, may cause exaggerated effect of succinylcholine-type neuromuscular blocking agents resulting in delayed recovery of neuromuscular function.

Potentiation and prolongation of neuromuscular blockade is possible. Magnesium suppresses peripheral neuromuscular function by decreasing acetylcholine release and reducing endplate sensitivity.

Potentiation and prolongation of neuromuscular blockade is possible. Magnesium suppresses peripheral neuromuscular function by decreasing acetylcholine release and reducing endplate sensitivity.

Prolonged paralysis reported when succinylcholine given with anticholinesterase-active drugs; use with caution.

Enhanced neuromuscular blockade during surgery; degree of blockade may be significantly increased by previously administered pyridostigmine.

Concomitant use associated with perioperative hyperkalemia risk.

Prior administration of succinylcholine enhances the neuromuscular blocking effect of vecuronium and prolongs its duration of action. Vecuronium administration should be delayed until succinylcholine effect wears off.

May enhance the neuromuscular blocking action of succinylcholine.

Pralidoxime reactivates cholinesterases, accelerating reversal of succinylcholine's neuromuscular blocking effects. Monitor neuromuscular effects with concomitant administration.

May enhance the neuromuscular blocking action of succinylcholine.

May decrease time to onset of maximum neuromuscular blockade. Use peripheral nerve stimulator and monitor clinical signs.

Desflurane reduces ED95 of succinylcholine by approximately 30%. Dose adjustment may be needed during maintenance anesthesia.

May enhance the neuromuscular blocking action of succinylcholine.

Furosemide may potentiate the action of succinylcholine.

Furosemide may potentiate the action of succinylcholine. Monitor for skeletal muscle effect.

Furosemide may potentiate the action of succinylcholine.

Isoflurane potentiates the muscle relaxant effect of succinylcholine, reducing required ED95 by approximately 25-40%. Dose adjustment required.

May enhance the neuromuscular blocking action of succinylcholine.

May enhance the neuromuscular blocking action of succinylcholine.

Concomitant use with succinylcholine may lead to synergistic cholinergic effects due to donepezil's cholinesterase inhibition.

May enhance the neuromuscular blocking action of succinylcholine.

Chronically administered oral contraceptives may enhance neuromuscular blocking effect by reducing plasma cholinesterase activity.

May enhance the neuromuscular blocking action of succinylcholine.

May enhance the neuromuscular blocking action of succinylcholine.

Patients taking procainamide may require less than usual doses of succinylcholine due to procainamide effects on reducing acetylcholine release.

May enhance the neuromuscular blocking action of succinylcholine.

May enhance the neuromuscular blocking action of succinylcholine.

May enhance the neuromuscular blocking action of succinylcholine.

May enhance the neuromuscular blocking action of succinylcholine.

Neuromuscular blocker succinylcholine may cause additive bradycardic effect with thalidomide and should be used with caution.

May enhance the neuromuscular blocking action of succinylcholine.

No clinically significant change in onset, intensity, or duration of action observed.

Metoclopramide inhibits plasma cholinesterase; interaction mentioned but severity not fully specified in text.

7 DRUG INTERACTIONS Drugs that May Enhance the Neuromuscular Blocking Action of Succinylcholine: promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, and drugs that reduce plasma cholinesterase activity. ( 7.1) 7.1 Drugs that May Affect the Neuromuscular Blocking Action of Succinylcholine Chloride Injection Drugs that may enhance the neuromuscular blocking action of succinylcholine include: promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, and terbutaline.

Use before succinylcholine has not been studied.