Sulfadiazine has 12 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Acidifying Agents, Andthiazide, Fosphenytoin Sodium. Patients taking Sulfadiazine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Moderate
- 11
Moderate (11)
- Sulfadiazine + Acidifying Agents— Potentiation of the action of uricosuric agents may be noted, possibly due to displacement from albumin or pharmacodynam…
- Sulfadiazine + Andthiazide— Potentiation of the action of thiazide diuretics may be noted, possibly due to displacement from albumin or pharmacodyna…
- Sulfadiazine + Fosphenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Sulfadiazine + Indomethacin— Indomethacin may displace sulfonamides from plasma albumin and increase concentrations of free drug in plasma.
- Sulfadiazine + Methotrexate— Sulfonamides may increase the effect of methotrexate, probably by displacement from plasma albumin binding sites.
- Sulfadiazine + Oral Anticoagulants— Sulfonamides may increase the effect of oral anticoagulants, probably by displacement from plasma albumin binding sites.
- Sulfadiazine + Phenytoin— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Sulfadiazine + Phenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Sulfadiazine + Probenecid— Probenecid may displace sulfonamides from plasma albumin and increase concentrations of free drug in plasma.
- Sulfadiazine + Salicylates— Salicylates may displace sulfonamides from plasma albumin and increase concentrations of free drug in plasma.
- Sulfadiazine + Sulfonylurea— Potentiation of the action of sulfonylurea hypoglycemic agents may be noted, possibly due to displacement from albumin o…