Does Sulfadiazine Interact with Indomethacin?
CDI records a moderate classification for Sulfadiazine and Indomethacin. The stored summary is: Indomethacin may displace sulfonamides from plasma albumin and increase concentrations of free drug in plasma. The mechanism involves displacement of sulfonamides from plasma albumin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Sulfadiazine Class
- Sulfonamide Antibacterial
- Indomethacin Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
displacement of sulfonamides from plasma albumin
What To Tell Your Doctor or Pharmacist
If you are taking Sulfadiazine and your doctor is considering prescribing Indomethacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider