CYP1A2 inhibitor; concomitant use should be avoided due to potential for hypotension, bradycardia, or excessive drowsiness.
Source: NLP:tizanidine
10 interactions on record
CYP1A2 inhibitor; concomitant use should be avoided due to potential for hypotension, bradycardia, or excessive drowsiness.
Source: NLP:tizanidine
Concomitant use should be avoided due to potential interactions. If clinically necessary, initiate with 2 mg and titrate cautiously.
Source: NLP:tizanidine hydrochloride
Should be avoided due to CYP1A2 inhibition. If necessary, initiate tizanidine at 2 mg and titrate cautiously; monitor for hypotension, bradycardia, or excessive drowsiness.
Source: NLP:tizanidne hydrochloride
CYP2B6 inhibitor that increases bupropion exposure and decreases hydroxybupropion exposure. Dosage adjustment of bupropion may be necessary based on clinical response.
Source: NLP:bupropion hcl er (xl)
CYP2B6 inhibitor that can increase bupropion exposure but decrease hydroxybupropion exposure. Dosage adjustment may be necessary.
Source: NLP:bupropion hydrochloride
CYP3A4 inhibitor that increases carbamazepine plasma levels. Close monitoring of carbamazepine levels and dosage adjustment may be required.
Source: NLP:carbamazepine
Strong CYP2C19 inhibitor that may increase exposure to N-desmethylclobazam active metabolite, increasing risk of dose-related adverse reactions.
Source: NLP:clobazam
May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
Source: NLP:fosphenytoin sodium
May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
Source: NLP:extended phenytoin sodium
CYP2C19 inhibitor that increases propranolol exposure. Monitor for bradycardia and hypotension.
Source: NLP:propranolol hydrochloride