Ticlopidine has 17 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Bupropion Hcl Er, Bupropion Hydrochloride, Tizanidine. Patients taking Ticlopidine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Contraindicated
- 2
- Major
- 5
- Moderate
- 10
Contraindicated (2)
- Ticlopidine + Bupropion Hcl Er— Coadministration not recommended due to increased bupropion exposure and decreased hydroxybupropion exposure.
- Ticlopidine + Bupropion Hydrochloride— Coadministration not recommended due to increased bupropion exposure and decreased hydroxybupropion exposure.
Major (5)
- Ticlopidine + Tizanidine— CYP1A2 inhibitor; concomitant use should be avoided due to potential for hypotension, bradycardia, or excessive drowsine…
- Ticlopidine + Tizanidine Hydrochloride— Concomitant use should be avoided due to potential interactions. If clinically necessary, initiate with 2 mg and titrate…
- Ticlopidine + Tizanidne Hydrochloride— Should be avoided due to CYP1A2 inhibition. If necessary, initiate tizanidine at 2 mg and titrate cautiously; monitor fo…
- Ticlopidine + Warfarin— CYP1A2 inhibitor that increases warfarin exposure and INR effect; requires close INR monitoring.
- Ticlopidine + Warfarin Sodium— CYP1A2 inhibitor that increases warfarin effect and INR; requires close monitoring.
Moderate (10)
- Ticlopidine + Bupropion— CYP2B6 inhibitor that increases bupropion exposure; dosage adjustment may be necessary based on clinical response.
- Ticlopidine + Bupropion Hcl Er (Xl)— CYP2B6 inhibitor that increases bupropion exposure and decreases hydroxybupropion exposure. Dosage adjustment of bupropi…
- Ticlopidine + Bupropion Hydrobromide— CYP2B6 inhibitor that can increase bupropion exposure while decreasing hydroxybupropion exposure. Dosage adjustment may …
- Ticlopidine + Carbamazepine— CYP3A4 inhibitor that increases carbamazepine plasma levels. Close monitoring of carbamazepine levels and dosage adjustm…
- Ticlopidine + Clobazam— Strong CYP2C19 inhibitor that may increase exposure to N-desmethylclobazam active metabolite, increasing risk of dose-re…
- Ticlopidine + Fosphenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Ticlopidine + Naltrexone Hydrochloride And Bupropion Hydrochloride— CYP2B6 inhibitor that can increase bupropion exposure. Do not exceed one tablet twice daily when taken with ticlopidine.
- Ticlopidine + Phenytoin— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Ticlopidine + Phenytoin Sodium— May increase phenytoin serum levels; monitoring of phenytoin levels recommended.
- Ticlopidine + Propranolol Hydrochloride— CYP2C19 inhibitor that increases propranolol exposure. Monitor for bradycardia and hypotension.