Does Ticlopidine Interact with Naltrexone Hydrochloride And Bupropion Hydrochloride?
Ticlopidine and Naltrexone Hydrochloride And Bupropion Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. CYP2B6 inhibitor that can increase bupropion exposure. Do not exceed one tablet twice daily when taken with ticlopidine. The mechanism involves cyp2b6 inhibition reducing bupropion metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ticlopidine and Naltrexone Hydrochloride And Bupropion Hydrochloride occurs because cyp2b6 inhibition reducing bupropion metabolism. Clinically, this means cyp2b6 inhibitor that can increase bupropion exposure. do not exceed one tablet twice daily when taken with ticlopidine. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ticlopidine and your doctor is considering prescribing Naltrexone Hydrochloride And Bupropion Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider