Roflumilast has 15 known drug interactions based on U.S. FDA drug labeling data. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Cimetidine, Enoxacin. Patients taking Roflumilast should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 15
- Major
- 9
- Moderate
- 5
Major (9)
- Roflumilast + Carbamazepine— Strong CYP450 enzyme inducer that decreases roflumilast systemic exposure and may reduce therapeutic effectiveness. Use …
- Roflumilast + Cimetidine— CYP3A4 and CYP1A2 inhibitor that increases roflumilast systemic exposure and may result in increased adverse reactions.
- Roflumilast + Enoxacin— CYP3A4 and CYP1A2 inhibitor that increases roflumilast systemic exposure and may result in increased adverse reactions.
- Roflumilast + Erythromycin— CYP3A4 and CYP1A2 inhibitor that increases roflumilast systemic exposure and may result in increased adverse reactions.
- Roflumilast + Fluvoxamine— CYP3A4 and CYP1A2 inhibitor that increases roflumilast systemic exposure and may result in increased adverse reactions.
- Roflumilast + Ketoconazole— CYP3A4 and CYP1A2 inhibitor that increases roflumilast systemic exposure and may result in increased adverse reactions.
- Roflumilast + Phenobarbital— Strong CYP450 enzyme inducer that decreases roflumilast systemic exposure and may reduce therapeutic effectiveness. Use …
- Roflumilast + Phenytoin— Strong CYP450 enzyme inducer that decreases roflumilast systemic exposure and may reduce therapeutic effectiveness. Use …
- Roflumilast + Rifampin— Strong CYP450 enzyme inducer that decreases roflumilast systemic exposure and may reduce therapeutic effectiveness. Use …
Moderate (5)
- Roflumilast + Dual Strong Cyp3a4 / Moderate Cyp1a2 Inducers— Co-administration may increase roflumilast systemic exposure and may result in increased adverse reactions. Weigh potent…
- Roflumilast + Ethinyl Estradiol— Oral contraceptive component that may increase roflumilast systemic exposure and result in increased side effects when c…
- Roflumilast + Gestodene— Oral contraceptive component that may increase roflumilast systemic exposure and result in increased side effects when c…
- Roflumilast + Gestodene And Ethinyl Estradiol— Oral contraceptive combination that may increase roflumilast systemic exposure and result in increased side effects. Ris…
- Roflumilast + Mao Inhibitors— Co-administration may increase roflumilast systemic exposure and may result in increased adverse reactions. Weigh potent…