Does Roflumilast Interact with Riociguat?
Roflumilast and Riociguat have a unknown drug interaction according to U.S. FDA drug labeling data. Clinical experience with co-administration is limited. The mechanism involves phosphodiesterase inhibitor interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Roflumilast Class
- Phosphodiesterase 4 Inhibitor
- Riociguat Class
- Soluble Guanylate Cyclase Stimulator
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Roflumilast and Riociguat occurs because phosphodiesterase inhibitor interaction. Clinically, this means clinical experience with co-administration is limited.
What To Tell Your Doctor or Pharmacist
If you are taking Roflumilast and your doctor is considering prescribing Riociguat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider