Does Roflumilast Interact with Riociguat?
CDI records a unknown classification for Roflumilast and Riociguat. The stored summary is: Clinical experience with co-administration is limited. The mechanism involves phosphodiesterase inhibitor interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Unknown
- Roflumilast Class
- Phosphodiesterase 4 Inhibitor
- Riociguat Class
- Soluble Guanylate Cyclase Stimulator
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Phosphodiesterase inhibitor interaction
What To Tell Your Doctor or Pharmacist
If you are taking Roflumilast and your doctor is considering prescribing Riociguat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider