Ascorbic Acid has 31 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Amphetamine, Amphetamine Sulfate, Bleomycin. Patients taking Ascorbic Acid should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 31
- Moderate
- 28
- Minor
- 3
Moderate (28)
- Ascorbic Acid + Amphetamine— Ascorbic acid may acidify urine and lower amphetamine serum concentrations by increasing renal excretion. Standard monit…
- Ascorbic Acid + Amphetamine Sulfate— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Ascorbic Acid + Bleomycin— Bleomycin is inactivated by ascorbic acid. Standard monitoring of antibiotic efficacy is warranted.
- Ascorbic Acid + Cupric Chloride— Cupric ion may degrade ascorbic acid in total parenteral nutrition (TPN) solutions, leading to loss of ascorbate. Multiv…
- Ascorbic Acid + Desogestrel And Ethinyl Estradiol And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Dextroamphetamine— Gastrointestinal acidifying agent lowers amphetamine absorption and blood levels, reducing efficacy.
- Ascorbic Acid + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— Acidifying agent that lowers blood levels and efficacy of amphetamines. Dose adjustment may be needed based on clinical …
- Ascorbic Acid + Dextroamphetamine Sulfate— Gastrointestinal acidifying agent that lowers amphetamine absorption and blood levels.
- Ascorbic Acid + Doxycycline— Ascorbic acid may decrease the activity of doxycycline. Standard monitoring of antibiotic efficacy is warranted.
- Ascorbic Acid + Drospirenone And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Drospirenone, Ethinyl Estradiol And Levomefolate Calcium And Levomefolate Calcium— May increase plasma ethinyl estradiol concentrations, possibly through inhibition of conjugation.
- Ascorbic Acid + Drospirenone/Ethinyl Estradiol/Levomefolate Calcium And Levomefolate Calcium— May increase plasma ethinyl estradiol concentrations possibly by inhibition of conjugation.
- Ascorbic Acid + Erythromycin— Ascorbic acid may decrease the activity of erythromycin. Standard monitoring of antibiotic efficacy is warranted.
- Ascorbic Acid + Etonogestrel And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Etonogestrel And Ethinyl Estradiol Vaginal Ring— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Fluphenazine— Concurrent administration of ascorbic acid and fluphenazine may result in decreased fluphenazine plasma concentrations. …
- Ascorbic Acid + Kanamycin— Ascorbic acid may decrease the activity of kanamycin. Standard monitoring of antibiotic efficacy is warranted.
- Ascorbic Acid + Levonorgestrel And Ethinyl Estradiol And Ferrous Fumarate— Ascorbic acid may increase plasma ethinyl estradiol levels.
- Ascorbic Acid + Levonorgestrel/Ethinyl Estradiol And Ethinyl Estradiol— May increase plasma ethinyl estradiol levels.
- Ascorbic Acid + Lincomycin— Ascorbic acid may decrease the activity of lincomycin. Standard monitoring of antibiotic efficacy is warranted.
- Ascorbic Acid + Norelgestromin And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Norethindrone Acetate, Ethinyl Estradiol And Ferrous Fumarate— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Norethindrone Acetate/Ethinyl Estradiol— May increase plasma ethinyl estradiol concentration, possibly by inhibition of conjugation.
- Ascorbic Acid + Norethindrone And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations.
- Ascorbic Acid + Norgestimate And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Segesterone Acetate And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Streptomycin— Ascorbic acid may decrease the activity of streptomycin. Standard monitoring of antibiotic efficacy is warranted.
- Ascorbic Acid + Warfarin— Interaction with warfarin noted. Continue standard monitoring.
Minor (3)
- Ascorbic Acid + Levonorgestrel And Ethinyl Estradiol And Ethinyl Estradiol Tablets— Ascorbic acid may increase plasma ethinyl estradiol concentrations, possibly by inhibition of conjugation.
- Ascorbic Acid + Norgestrel And Ethinyl Estradiol— May increase plasma ethinyl estradiol concentrations.
- Ascorbic Acid + Zinc Acetate— Pharmacodynamic studies in Wilson's disease patients showed no drug interactions between zinc acetate and ascorbic acid.…