Phentermine And Topiramate Extended-Release has 8 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Monoamine Oxidase Inhibitors (Maois), Alcohol, Barbiturates. Patients taking Phentermine And Topiramate Extended-Release should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Contraindicated
- 1
- Moderate
- 7
Contraindicated (1)
- Phentermine And Topiramate Extended-Release + Monoamine Oxidase Inhibitors (Maois)— Concomitant use of phentermine with MAOIs increases the risk of hypertensive crisis. Contraindicated during MAOI treatme…
Moderate (7)
- Phentermine And Topiramate Extended-Release + Alcohol— Concomitant use may potentiate CNS depression such as dizziness or cognitive adverse reactions. Caution against excessiv…
- Phentermine And Topiramate Extended-Release + Barbiturates— Concomitant use with CNS depressants may potentiate CNS depression such as dizziness or cognitive adverse reactions.
- Phentermine And Topiramate Extended-Release + Hydrochlorothiazide— Concomitant administration increases topiramate Cmax by 27% and AUC by 29%, requiring potassium monitoring.
- Phentermine And Topiramate Extended-Release + Nitrazepam— Concomitant use with CNS depressants may potentiate CNS depression such as dizziness or cognitive adverse reactions.
- Phentermine And Topiramate Extended-Release + Norethindrone And Ethinyl Estradiol— Co-administration decreases ethinyl estradiol exposure by 16% and increases norethindrone exposure by 22%, potentially c…
- Phentermine And Topiramate Extended-Release + Potassium Supplements— Concurrent use may potentiate the potassium-wasting action of diuretics, requiring monitoring of potassium levels before…
- Phentermine And Topiramate Extended-Release + Sleep Medications— Concomitant use with CNS depressants may potentiate CNS depression such as dizziness or cognitive adverse reactions.