Does Phentermine And Topiramate Extended Release Interact with Hydrochlorothiazide?
CDI records a moderate classification for Phentermine And Topiramate Extended Release and Hydrochlorothiazide. The stored summary is: Concomitant administration increases topiramate Cmax by 27% and AUC by 29%, requiring potassium monitoring. The mechanism involves increased topiramate exposure with potassium-wasting potential. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Phentermine And Topiramate Extended Release Class
- Cytochrome P450 3A4 Inducers
- Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased topiramate exposure with potassium-wasting potential
What To Tell Your Doctor or Pharmacist
If you are taking Phentermine And Topiramate Extended Release and your doctor is considering prescribing Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider