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Other Anticholinergic Agents

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50 interactions on record

Other Anticholinergic Agents has 50 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 23 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Diethylpropion Hydrochloride, Benzphetamine Hydrochloride, Betaxolol. Patients taking Other Anticholinergic Agents should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 50
Contraindicated: 1
Major: 23
Moderate: 25

Contraindicated (1)

Other Anticholinergic Agents + Diethylpropion Hydrochloride— Combined use may have potential for serious cardiac problems; efficacy has not been studied.

Major (23)

Other Anticholinergic Agents + Benzphetamine Hydrochloride— Combined use with other anorectic agents has not been studied and may have potential for serious cardiac problems.
Other Anticholinergic Agents + Betaxolol— Anesthetic agent that depresses the myocardium; particular care needed when used with beta-blockers.
Other Anticholinergic Agents + Buprenorphine— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive opioid effe…
Other Anticholinergic Agents + Butalbital, Acetaminophen And Caffeine— CNS depressants may enhance effects and cause increased CNS depression.
Other Anticholinergic Agents + Butalbital, Aspirin, And Caffeine— Butalbital causes increased CNS depression when combined with other narcotic analgesics.
Other Anticholinergic Agents + Butorphanol Tartrate— Additive CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
Other Anticholinergic Agents + Citalopram— Concomitant use increases risk of serotonin syndrome.
Other Anticholinergic Agents + Citalopram Hydrobromide— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and…
Other Anticholinergic Agents + Colistimethate— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
Other Anticholinergic Agents + Colistimethate Sodium— Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colisti…
Other Anticholinergic Agents + Escitalopram— Concomitant use increases the risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during i…
Other Anticholinergic Agents + Fluoxetine— Concomitant use increases risk of serotonin syndrome; monitor for signs and symptoms.
Other Anticholinergic Agents + Fluoxetine Hydrochloride— Concomitant use increases risk of serotonin syndrome; monitor for symptoms.
Other Anticholinergic Agents + Ketamine Hydrochloride— Concomitant use may result in profound sedation, respiratory depression, coma, or death.
Other Anticholinergic Agents + Levorphanol Tartrate— Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.
Other Anticholinergic Agents + Methadone Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Other Anticholinergic Agents + Methylnaltrexone Bromide— Avoid concomitant use due to potential additive effects of opioid receptor antagonism and increased risk of opioid withd…
Other Anticholinergic Agents + Morphine Sulfate— Additive CNS depressant effects increase risk of hypotension, respiratory depression, profound sedation, coma, and death…
Other Anticholinergic Agents + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use increases risk of hypotension, respiratory depression, profound sedation, coma, and death due to additiv…
Other Anticholinergic Agents + Phendimetrazine Tartrate— Combined use may have the potential for serious cardiac problems. Efficacy has not been studied.
Other Anticholinergic Agents + Remifentanil Hydrochloride— CNS depressants increase risk of hypotension, respiratory depression, profound sedation, coma, and death.
Other Anticholinergic Agents + Sertraline Hydrochloride— Concomitant use increases the risk of serotonin syndrome.
Other Anticholinergic Agents + Venlafaxine Hydrochloride— Potential for serotonin syndrome. Careful patient observation advised, particularly during treatment initiation and dose…

Moderate (25)

Other Anticholinergic Agents + Acetaminophen And Codeine Phosphate— May enhance CNS depressant effects, causing increased CNS depression.
Other Anticholinergic Agents + Amantadine— Anticholinergic drugs may potentiate anticholinergic-like side effects of amantadine. Dose reduction recommended if atro…
Other Anticholinergic Agents + Amiloride Hydrochloride And Hydrochlorothiazide— Additive effect or potentiation may occur when used concurrently with hydrochlorothiazide.
Other Anticholinergic Agents + Butalbital And Acetaminophen Tablets— Other CNS depressants may have enhanced effects when combined with butalbital and acetaminophen, causing increased CNS d…
Other Anticholinergic Agents + Cabotegravir Sodium— Coadministration of VOCABRIA with other antiretroviral medications for PrEP is not recommended.
Other Anticholinergic Agents + Chlorothiazide Sodium— Additive effect or potentiation of antihypertensive response may occur with concurrent use of chlorothiazide sodium.
Other Anticholinergic Agents + Darifenacin Hydrobromide— Concomitant use may increase frequency and/or severity of dry mouth, constipation, blurred vision and other anticholiner…
Other Anticholinergic Agents + Desmopressin Acetate— May require reduction of Desmopressin Acetate dosage due to additive blood pressure elevation.
Other Anticholinergic Agents + Desvenlafaxine Er— Concomitant use increases risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Other Anticholinergic Agents + Doxepin Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and…
Other Anticholinergic Agents + Epoprostenol— Additional reductions in blood pressure may occur when epoprostenol is administered with other vasodilators.
Other Anticholinergic Agents + Glipizide And Metformin Hydrochloride— Diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation needed for loss…
Other Anticholinergic Agents + Hydrochlorothiazide— Additive effect or potentiation may occur when given concurrently.
Other Anticholinergic Agents + Hyoscyamine Sulfate— Drug interactions may occur when hyoscyamine sulfate is used with other anticholinergics.
Other Anticholinergic Agents + Indapamide— Indapamide may add to or potentiate the action of other antihypertensive drugs, requiring monitoring for enhanced hypote…
Other Anticholinergic Agents + Irbesartan And Hydrochlorothiazide— Additive effect or potentiation of antihypertensive response may occur.
Other Anticholinergic Agents + Latanoprost Ophthalmic Solution 0.005%— Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily…
Other Anticholinergic Agents + Metolazone— Care must be taken during initial therapy; dosage adjustments of other antihypertensives may be necessary.
Other Anticholinergic Agents + Paroxetine— Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms.
Other Anticholinergic Agents + Somatropin— NORDITROPIN may decrease insulin sensitivity, requiring adjustment of hypoglycemic agent doses, particularly at higher N…
Other Anticholinergic Agents + Tolterodine— Concomitant use may increase frequency and/or severity of dry mouth, constipation, blurred vision, somnolence, and other…
Other Anticholinergic Agents + Tolterodine Tartrate— Concomitant use may increase frequency and/or severity of dry mouth, constipation, blurred vision, somnolence, and other…
Other Anticholinergic Agents + Triamterene— Effects of other diuretics may be potentiated when given with triamterene.
Other Anticholinergic Agents + Triamterene Capsules— Effects may be potentiated when given together with triamterene.
Other Anticholinergic Agents + Vilazodone Hydrochloride— Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initi…

Other Anticholinergic Agents + Diethylpropion Hydrochloride⛔Contraindicated

Combined use may have potential for serious cardiac problems; efficacy has not been studied.

Other Anticholinergic Agents + Benzphetamine Hydrochloride⚠️Major

Combined use with other anorectic agents has not been studied and may have potential for serious cardiac problems.

Other Anticholinergic Agents + Betaxolol⚠️Major

Anesthetic agent that depresses the myocardium; particular care needed when used with beta-blockers.

Other Anticholinergic Agents + Buprenorphine⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive opioid effects.

Other Anticholinergic Agents + Butalbital, Acetaminophen And Caffeine⚠️Major

CNS depressants may enhance effects and cause increased CNS depression.

Other Anticholinergic Agents + Butalbital, Aspirin, And Caffeine⚠️Major

Butalbital causes increased CNS depression when combined with other narcotic analgesics.

Other Anticholinergic Agents + Butorphanol Tartrate⚠️Major

Additive CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.

Other Anticholinergic Agents + Citalopram⚠️Major

Concomitant use increases risk of serotonin syndrome.

Other Anticholinergic Agents + Citalopram Hydrobromide⚠️Major

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and dosage increases.

Other Anticholinergic Agents + Colistimethate⚠️Major

Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.

Other Anticholinergic Agents + Colistimethate Sodium⚠️Major

Potentiates neuromuscular blocking effect and should be used with extreme caution in patients being treated with colistimethate.

Other Anticholinergic Agents + Escitalopram⚠️Major

Concomitant use increases the risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initiation and dosage increases.

Other Anticholinergic Agents + Fluoxetine⚠️Major

Concomitant use increases risk of serotonin syndrome; monitor for signs and symptoms.

Other Anticholinergic Agents + Fluoxetine Hydrochloride⚠️Major

Concomitant use increases risk of serotonin syndrome; monitor for symptoms.

Other Anticholinergic Agents + Ketamine Hydrochloride⚠️Major

Concomitant use may result in profound sedation, respiratory depression, coma, or death.

Other Anticholinergic Agents + Levorphanol Tartrate⚠️Major

Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.

Other Anticholinergic Agents + Methadone Hydrochloride⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Other Anticholinergic Agents + Methylnaltrexone Bromide⚠️Major

Avoid concomitant use due to potential additive effects of opioid receptor antagonism and increased risk of opioid withdrawal.

Other Anticholinergic Agents + Morphine Sulfate⚠️Major

Additive CNS depressant effects increase risk of hypotension, respiratory depression, profound sedation, coma, and death.

Other Anticholinergic Agents + Pentazocine Hydrochloride And Naloxone Hydrochloride⚠️Major

Concomitant use increases risk of hypotension, respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Other Anticholinergic Agents + Phendimetrazine Tartrate⚠️Major

Combined use may have the potential for serious cardiac problems. Efficacy has not been studied.

Other Anticholinergic Agents + Remifentanil Hydrochloride⚠️Major

CNS depressants increase risk of hypotension, respiratory depression, profound sedation, coma, and death.

Other Anticholinergic Agents + Sertraline Hydrochloride⚠️Major

Concomitant use increases the risk of serotonin syndrome.

Other Anticholinergic Agents + Venlafaxine Hydrochloride⚠️Major

Potential for serotonin syndrome. Careful patient observation advised, particularly during treatment initiation and dose increases.

Other Anticholinergic Agents + Acetaminophen And Codeine Phosphate🟡Moderate

May enhance CNS depressant effects, causing increased CNS depression.

Other Anticholinergic Agents + Amantadine🟡Moderate

Anticholinergic drugs may potentiate anticholinergic-like side effects of amantadine. Dose reduction recommended if atropine-like effects occur.

Other Anticholinergic Agents + Amiloride Hydrochloride And Hydrochlorothiazide🟡Moderate

Additive effect or potentiation may occur when used concurrently with hydrochlorothiazide.

Other Anticholinergic Agents + Butalbital And Acetaminophen Tablets🟡Moderate

Other CNS depressants may have enhanced effects when combined with butalbital and acetaminophen, causing increased CNS depression.

Other Anticholinergic Agents + Cabotegravir Sodium🟡Moderate

Coadministration of VOCABRIA with other antiretroviral medications for PrEP is not recommended.

Other Anticholinergic Agents + Chlorothiazide Sodium🟡Moderate

Additive effect or potentiation of antihypertensive response may occur with concurrent use of chlorothiazide sodium.

Other Anticholinergic Agents + Darifenacin Hydrobromide🟡Moderate

Concomitant use may increase frequency and/or severity of dry mouth, constipation, blurred vision and other anticholinergic effects; may alter absorption of other drugs via GI motility effects.

Other Anticholinergic Agents + Desmopressin Acetate🟡Moderate

May require reduction of Desmopressin Acetate dosage due to additive blood pressure elevation.

Other Anticholinergic Agents + Desvenlafaxine Er🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.

Other Anticholinergic Agents + Doxepin Hydrochloride🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms, particularly during initiation and dosage increases.

Other Anticholinergic Agents + Epoprostenol🟡Moderate

Additional reductions in blood pressure may occur when epoprostenol is administered with other vasodilators.

Other Anticholinergic Agents + Glipizide And Metformin Hydrochloride🟡Moderate

Diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation needed for loss of blood glucose control.

Other Anticholinergic Agents + Hydrochlorothiazide🟡Moderate

Additive effect or potentiation may occur when given concurrently.

Other Anticholinergic Agents + Hyoscyamine Sulfate🟡Moderate

Drug interactions may occur when hyoscyamine sulfate is used with other anticholinergics.

Other Anticholinergic Agents + Indapamide🟡Moderate

Indapamide may add to or potentiate the action of other antihypertensive drugs, requiring monitoring for enhanced hypotensive effects.

Other Anticholinergic Agents + Irbesartan And Hydrochlorothiazide🟡Moderate

Additive effect or potentiation of antihypertensive response may occur.

Other Anticholinergic Agents + Latanoprost Ophthalmic Solution 0.005%🟡Moderate

Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily may decrease IOP lowering effect or cause paradoxical IOP elevations.

Other Anticholinergic Agents + Metolazone🟡Moderate

Care must be taken during initial therapy; dosage adjustments of other antihypertensives may be necessary.

Other Anticholinergic Agents + Paroxetine🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor for signs and symptoms.

Other Anticholinergic Agents + Somatropin🟡Moderate

NORDITROPIN may decrease insulin sensitivity, requiring adjustment of hypoglycemic agent doses, particularly at higher NORDITROPIN doses.

Other Anticholinergic Agents + Tolterodine🟡Moderate

Concomitant use may increase frequency and/or severity of dry mouth, constipation, blurred vision, somnolence, and other anticholinergic pharmacological effects.

Other Anticholinergic Agents + Tolterodine Tartrate🟡Moderate

Concomitant use may increase frequency and/or severity of dry mouth, constipation, blurred vision, somnolence, and other anticholinergic effects.

Other Anticholinergic Agents + Triamterene🟡Moderate

Effects of other diuretics may be potentiated when given with triamterene.

Other Anticholinergic Agents + Triamterene Capsules🟡Moderate

Effects may be potentiated when given together with triamterene.

Other Anticholinergic Agents + Vilazodone Hydrochloride🟡Moderate

Concomitant use increases risk of serotonin syndrome. Monitor patients for signs and symptoms, particularly during initiation.

Other Anticholinergic Agents + Ribavirinℹ️Unknown

Clinical studies of interactions with other antiviral agents have not been conducted; potential interaction unknown.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.