Apixaban has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 4 are contraindicated combinations that should be avoided entirely. 8 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Phenytoin, Rifampin. Patients taking Apixaban should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Contraindicated
- 4
- Major
- 8
- Moderate
- 1
Contraindicated (4)
- Apixaban + Carbamazepine— Combined P-gp and strong CYP3A4 inducer that decreases apixaban exposure and increases risk of stroke and thromboembolic…
- Apixaban + Phenytoin— Combined P-gp and strong CYP3A4 inducer that decreases apixaban exposure and increases risk of stroke and thromboembolic…
- Apixaban + Rifampin— Combined P-gp and strong CYP3A4 inducer that decreases apixaban exposure and increases risk of stroke and thromboembolic…
- Apixaban + St. John'S Wort— Combined P-gp and strong CYP3A4 inducer that decreases apixaban exposure and increases risk of stroke and thromboembolic…
Major (8)
- Apixaban + Aspirin— Antiplatelet agent that increases bleeding risk when coadministered with apixaban. Concomitant use increased major bleed…
- Apixaban + Clopidogrel— Antiplatelet agent that increases bleeding risk when coadministered with apixaban. Dual antiplatelet therapy with apixab…
- Apixaban + Heparin— Anticoagulant that increases bleeding risk when coadministered with apixaban.
- Apixaban + Itraconazole— Itraconazole increases apixaban concentrations. Not recommended during and 2 weeks after itraconazole treatment.
- Apixaban + Ketoconazole— Combined P-gp and strong CYP3A4 inhibitor that increases apixaban exposure and bleeding risk. Reduce apixaban dose by 50…
- Apixaban + Mao Inhibitors— Fibrinolytic agents increase bleeding risk when coadministered with apixaban.
- Apixaban + Ritonavir— Combined P-gp and strong CYP3A4 inhibitor that increases apixaban exposure and bleeding risk. Reduce apixaban dose by 50…
- Apixaban + Warfarin— Anticoagulant that increases bleeding risk when coadministered with apixaban. Concomitant use with aspirin and warfarin …
Moderate (1)
- Apixaban + Clarithromycin— Combined P-gp and strong CYP3A4 inhibitor, but pharmacokinetic data suggest no dose adjustment is necessary with concomi…