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Does Apixaban Interact with Clopidogrel?

Apixaban and Clopidogrel have a major drug interaction according to U.S. FDA drug labeling data. Antiplatelet agent that increases bleeding risk when coadministered with apixaban. Dual antiplatelet therapy with apixaban resulted in 5.9% major bleeding per year versus 2.5% with placebo. The mechanism involves additive antiplatelet effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Apixaban Class
Factor Xa Inhibitor
Clopidogrel Class
P2Y12 Platelet Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Apixaban and Clopidogrel occurs because additive antiplatelet effects. Clinically, this means antiplatelet agent that increases bleeding risk when coadministered with apixaban. dual antiplatelet therapy with apixaban resulted in 5.9% major bleeding per year versus 2.5% with placebo. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Apixaban and your doctor is considering prescribing Clopidogrel (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Apixaban(Eliquis)+💊 Clopidogrel(Clopidogrel)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Factor Xa Inhibitor
Drug B class
P2Y12 Platelet Inhibitor
Source
NLP:apixaban

What this means in plain English

Antiplatelet agent that increases bleeding risk when coadministered with apixaban. Dual antiplatelet therapy with apixaban resulted in 5.9% major bleeding per year versus 2.5% with placebo.

What the FDA label says

"Additive antiplatelet effects"

📖 Source: NLP:apixaban

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.