Doxorubicin Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dexrazoxane, Trastuzumab, Anthracycline. Patients taking Doxorubicin Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 2
- Major
- 7
- Moderate
- 1
Contraindicated (2)
- Doxorubicin Hydrochloride + Dexrazoxane— Do not administer dexrazoxane as a cardioprotectant at the initiation of doxorubicin hydrochloride-containing chemothera…
- Doxorubicin Hydrochloride + Trastuzumab— Concurrent use results in increased risk of cardiac dysfunction. Do not administer doxorubicin in combination with trast…
Major (7)
- Doxorubicin Hydrochloride + Anthracycline— Therefore, avoid anthracycline-based therapy for up to 7 months after stopping trastuzumab when possible. If anthracycli…
- Doxorubicin Hydrochloride + Mercaptopurine— Doxorubicin may potentiate 6-mercaptopurine-induced hepatotoxicity, resulting in hepatic dysfunction with elevated bilir…
- Doxorubicin Hydrochloride + Paclitaxel— When given prior to doxorubicin hydrochloride, increases plasma concentrations of doxorubicin and its metabolites. Admin…
- Doxorubicin Hydrochloride + Phenobarbital— CYP3A4 inducer that may decrease doxorubicin concentration and clinical effect.
- Doxorubicin Hydrochloride + Phenytoin— CYP3A4 inducer that may decrease doxorubicin concentration and clinical effect.
- Doxorubicin Hydrochloride + St. John'S Wort— CYP3A4 inducer that may decrease doxorubicin concentration and clinical effect.
- Doxorubicin Hydrochloride + Verapamil— CYP3A4 inhibitor that increases doxorubicin concentration and clinical effect. Clinically significant interaction report…
Moderate (1)
- Doxorubicin Hydrochloride + Carbamazepine— CYP3A4 inducer that decreases carbamazepine plasma levels; monitoring and dosage adjustment may be necessary.