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Does Doxorubicin Hydrochloride Interact with Paclitaxel?

Doxorubicin Hydrochloride and Paclitaxel have a major drug interaction according to U.S. FDA drug labeling data. When given prior to doxorubicin hydrochloride, increases plasma concentrations of doxorubicin and its metabolites. Administer doxorubicin prior to paclitaxel if used concomitantly. The mechanism involves increased plasma concentrations of doxorubicin hydrochloride and metabolites. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Paclitaxel Class
Microtubule Inhibitor
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Doxorubicin Hydrochloride and Paclitaxel occurs because increased plasma concentrations of doxorubicin hydrochloride and metabolites. Clinically, this means when given prior to doxorubicin hydrochloride, increases plasma concentrations of doxorubicin and its metabolites. administer doxorubicin prior to paclitaxel if used concomitantly. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Doxorubicin Hydrochloride and your doctor is considering prescribing Paclitaxel (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Doxorubicin Hydrochloride(Doxorubicin Hydrochloride)+💊 Paclitaxel(Paclitaxel Protein-Bound Particles For Injectable Suspension (Albumin-Bound))

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Microtubule Inhibitor
Source
NLP:doxorubicin hydrochloride

What this means in plain English

When given prior to doxorubicin hydrochloride, increases plasma concentrations of doxorubicin and its metabolites. Administer doxorubicin prior to paclitaxel if used concomitantly.

What the FDA label says

"Increased plasma concentrations of doxorubicin hydrochloride and metabolites"

📖 Source: NLP:doxorubicin hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.