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Hydrocodone Bitartrate

Also known as: Hydrocodone Bitartrate

Route: Oral

Check Hydrocodone Bitartrate Interactions →

9 interactions on record⛔ Black Box Warning

Hydrocodone Bitartrate has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Nitrazepam, Carbamazepine. Patients taking Hydrocodone Bitartrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Contraindicated: 2
Major: 7

Contraindicated (2)

Hydrocodone Bitartrate + Alcohol— CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death. Concomita…
Hydrocodone Bitartrate + Nitrazepam— CNS depressants that increase risk of hypotension, respiratory depression, profound sedation, coma, and death. Concomita…

Major (7)

Hydrocodone Bitartrate + Carbamazepine— CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. …
Hydrocodone Bitartrate + Erythromycin— CYP3A4 inhibitor that increases hydrocodone plasma concentration, resulting in increased or prolonged opioid effects inc…
Hydrocodone Bitartrate + Hydrocodone— 7 DRUG INTERACTIONS Alcohol Clinical Impact: Concomitant use of alcohol with hydrocodone bitartrate extended-release cap…
Hydrocodone Bitartrate + Ketoconazole— CYP3A4 inhibitor that increases hydrocodone plasma concentration, resulting in increased or prolonged opioid effects inc…
Hydrocodone Bitartrate + Phenytoin— CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. …
Hydrocodone Bitartrate + Rifampin— CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. …
Hydrocodone Bitartrate + Ritonavir— CYP3A4 inhibitor that increases hydrocodone plasma concentration, resulting in increased or prolonged opioid effects inc…

Hydrocodone Bitartrate + Alcohol⛔Contraindicated

CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death. Concomitant use should be reserved for patients with inadequate alternatives.

Hydrocodone Bitartrate + Nitrazepam⛔Contraindicated

CNS depressants that increase risk of hypotension, respiratory depression, profound sedation, coma, and death. Concomitant use should be reserved for patients with inadequate alternatives.

Hydrocodone Bitartrate + Carbamazepine⚠️Major

CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Discontinuation may cause serious respiratory depression.

Hydrocodone Bitartrate + Erythromycin⚠️Major

CYP3A4 inhibitor that increases hydrocodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Hydrocodone Bitartrate + Hydrocodone⚠️Major

7 DRUG INTERACTIONS Alcohol Clinical Impact: Concomitant use of alcohol with hydrocodone bitartrate extended-release capsules can result in an increase of hydrocodone plasma levels and potentially fatal overdose of hydrocodone. Intervention: Instruct patients not to consume alcoholic beverages or use prescription or non-prescription products containing alcohol while on hydrocodone bitartrate extended-release capsules therapy [see Clinical Pharmacology ( 12.3 )] . Inhibitors of CYP3A4 and CYP2D6 Clinical Impact: The concomitant use of hydrocodone bitartrate extended-release capsules and CYP3A4 inhibitors can increase the plasma concentration of hydrocodone, resulting in increased or prolonged opioid effects.

Hydrocodone Bitartrate + Ketoconazole⚠️Major

CYP3A4 inhibitor that increases hydrocodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Hydrocodone Bitartrate + Phenytoin⚠️Major

CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Discontinuation may cause serious respiratory depression.

Hydrocodone Bitartrate + Rifampin⚠️Major

CYP3A4 inducer that decreases hydrocodone plasma concentration, resulting in decreased efficacy or withdrawal syndrome. Discontinuation may cause serious respiratory depression.

Hydrocodone Bitartrate + Ritonavir⚠️Major

CYP3A4 inhibitor that increases hydrocodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.