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Does Hydrocodone Bitartrate Interact with Hydrocodone?

CDI records a major classification for Hydrocodone Bitartrate and Hydrocodone. The stored summary is: 7 DRUG INTERACTIONS Alcohol Clinical Impact: Concomitant use of alcohol with hydrocodone bitartrate extended-release capsules can result in an increase of hydrocodone plasma levels and potentially fatal overdose of hydrocodone. Intervention: Instruct patients not to consume alcoholic beverages or use prescription or non-prescription products containing alcohol while on hydrocodone bitartrate extended-release capsules therapy [see Clinical Pharmacology ( 12.3 )] . Inhibitors of CYP3A4 and CYP2D6 Clinical Impact: The concomitant use of hydrocodone bitartrate extended-release capsules and CYP3A4 inhibitors can increase the plasma concentration of hydrocodone, resulting in increased or prolonged opioid effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity: Major
Management: Close medical supervision required
Data Source: U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Hydrocodone Bitartrate and your doctor is considering prescribing Hydrocodone (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask how frequently you should be monitored while these are co-prescribed
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Hydrocodone Bitartrate(Ibudone)+💊 Hydrocodone(Ibudone)

Severity & Interaction Details

⚠️

major

Use with caution — major interaction

Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

FDA drug label - hydrocodone bitartrate

What this means in plain English

7 DRUG INTERACTIONS Alcohol Clinical Impact: Concomitant use of alcohol with hydrocodone bitartrate extended-release capsules can result in an increase of hydrocodone plasma levels and potentially fatal overdose of hydrocodone. Intervention: Instruct patients not to consume alcoholic beverages or use prescription or non-prescription products containing alcohol while on hydrocodone bitartrate extended-release capsules therapy [see Clinical Pharmacology ( 12.3 )] . Inhibitors of CYP3A4 and CYP2D6 Clinical Impact: The concomitant use of hydrocodone bitartrate extended-release capsules and CYP3A4 inhibitors can increase the plasma concentration of hydrocodone, resulting in increased or prolonged opioid effects.

About Hydrocodone Bitartrate and Hydrocodone

You may recognize them by the brand names Ibudone and Ibudone. Hydrocodone Bitartrate additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: FDA drug label - hydrocodone bitartrate

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

FDA

FDA Safety Alert: Xylocaine (lidocaine HCl Injection, USP), 1%, 200 mg per 20 mL (10 mg per mL), 25 Multiple-Dose Vialabout Hydrocodone Bitartrate · 2026-07

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Check Hydrocodone Bitartrate and Hydrocodone against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.