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Lidocaine Hydrochloride

Also known as: Lidocaine Hydrochloride

Route: Epidural, Infiltration, Intracaudal, Perineural

Check Lidocaine Hydrochloride Interactions →

54 interactions on record⛔ Black Box Warning

Lidocaine Hydrochloride has 54 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 45 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ergot-Type Oxytocic Drugs, Acetaminophen, Acetazolamide. Patients taking Lidocaine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 54
Contraindicated: 1
Major: 45
Moderate: 8

Contraindicated (1)

Lidocaine Hydrochloride + Ergot-Type Oxytocic Drugs— Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents. Avoid use concomitantl…

Major (45)

Lidocaine Hydrochloride + Acetaminophen— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Acetazolamide— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Amiodarone— Cardiac effects may be additive or antagonistic and toxic effects may be additive when administered with lidocaine.
Lidocaine Hydrochloride + Anti-Arrhythmics— Concurrent use with lidocaine solutions containing epinephrine or norepinephrine may produce severe, prolonged hypertens…
Lidocaine Hydrochloride + Articaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Benzocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Bupivacaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Chloroquine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Cyclophosphamide— 7.5 Drugs Associated with Methemoglobinemia Patients that are administered local anesthetics may be at increased risk of…
Lidocaine Hydrochloride + Dapsone— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Digitalis Glycosides— Monitor toxicity when lidocaine is used in patients with digitalis toxicity accompanied by supraventricular arrhythmia a…
Lidocaine Hydrochloride + Epinephrine— Administration of lidocaine with epinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepress…
Lidocaine Hydrochloride + Flutamide— 7.5 Drugs Associated with Methemoglobinemia Patients that are administered local anesthetics may be at increased risk of…
Lidocaine Hydrochloride + Fluvoxamine— CYP1A2 inhibitor that increases lidocaine plasma AUC by 71% and Cmax by 22%, decreases clearance by 41%-60%, and prolong…
Lidocaine Hydrochloride + Hydroxyurea— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Ifosfamide— 7.5 Drugs Associated with Methemoglobinemia Patients that are administered local anesthetics may be at increased risk of…
Lidocaine Hydrochloride + Mepivacaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Metoclopramide— 7.5 Drugs Associated with Methemoglobinemia Patients that are administered local anesthetics may be at increased risk of…
Lidocaine Hydrochloride + Mexiletine— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with cautio…
Lidocaine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)— Administration of lidocaine solutions containing epinephrine may produce severe, prolonged hypertension. Concurrent use …
Lidocaine Hydrochloride + Nitric Oxide— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Nitrofurantoin— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Nitroglycerin— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Nitroprusside— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Nitrous Oxide— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Nonselective Beta-Adrenergic Antagonists— Administration of lidocaine solutions containing epinephrine may cause severe hypertension and bradycardia. Concurrent u…
Lidocaine Hydrochloride + Norepinephrine— Administration of lidocaine with norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepr…
Lidocaine Hydrochloride + Para-Aminosalicyclic Acid— Increased risk of methemoglobinemia when lidocaine hydrochloride is used concurrently with this antibiotic oxidizing age…
Lidocaine Hydrochloride + Para-Aminosalicylic Acid— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Phenobarbital— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Phenytoin— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Prilocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Primaquine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Procainamide— Cardiac effects may be additive or antagonistic and toxic effects may be additive when administered with lidocaine.
Lidocaine Hydrochloride + Procaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Quinidine— Cardiac effects may be additive or antagonistic and toxic effects may be additive when administered with lidocaine.
Lidocaine Hydrochloride + Quinine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Rasburicase— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Ropivacaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Sulfasalazine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Tetracaine— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Tocainide— Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with cautio…
Lidocaine Hydrochloride + Topical Local Anesthetics— Serious dose-related cardiac arrhythmias may occur if lidocaine solutions containing epinephrine are used during or foll…
Lidocaine Hydrochloride + Valproate Sodium— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
Lidocaine Hydrochloride + Vasopressin— Concurrent administration with ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular ac…

Moderate (8)

Lidocaine Hydrochloride + Butyrophenones— May reduce or reverse the pressor effect of epinephrine in lidocaine solutions; concurrent use should generally be avoid…
Lidocaine Hydrochloride + Cimetidine— Concomitant use may reduce hepatic blood flow and lidocaine clearance, increasing incidence of adverse reactions includi…
Lidocaine Hydrochloride + Local Anesthetics (Articaine, Benzocaine, Lidocaine, Mepivacaine, Prilocaine, Procaine, Ropivacaine, Tetracaine)— Toxic effects of local anesthetics are additive. Monitor patients for neurologic and cardiovascular effects related to l…
Lidocaine Hydrochloride + Nitrates— Patients at increased risk of developing methemoglobinemia when concurrently exposed to nitrates and lidocaine.
Lidocaine Hydrochloride + Nitrites— Patients at increased risk of developing methemoglobinemia when concurrently exposed to nitrites and lidocaine.
Lidocaine Hydrochloride + Phenothiazines— May reduce or reverse the pressor effect of epinephrine in lidocaine solutions; concurrent use should generally be avoid…
Lidocaine Hydrochloride + Propofol— CYP3A4 inhibitor that may increase lidocaine plasma levels by reducing lidocaine clearance.
Lidocaine Hydrochloride + Propranolol— May increase lidocaine plasma levels by decreasing hepatic blood flow and clearance; also may cause additive cardiac eff…

Lidocaine Hydrochloride + Ergot-Type Oxytocic Drugs⛔Contraindicated

Concurrent administration may cause severe, persistent hypertension or cerebrovascular accidents. Avoid use concomitantly.

Lidocaine Hydrochloride + Acetaminophen⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Acetazolamide⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Amiodarone⚠️Major

Cardiac effects may be additive or antagonistic and toxic effects may be additive when administered with lidocaine.

Lidocaine Hydrochloride + Anti-Arrhythmics⚠️Major

Concurrent use with lidocaine solutions containing epinephrine or norepinephrine may produce severe, prolonged hypertension.

Lidocaine Hydrochloride + Articaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Benzocaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Bupivacaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Chloroquine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Cyclophosphamide⚠️Major

7.5 Drugs Associated with Methemoglobinemia Patients that are administered local anesthetics may be at increased risk of developing methemoglobinemia when concurrently exposed to the following oxidizing agents: Class Examples Nitrates/Nitrites nitroglycerin, nitroprusside, nitric oxide, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, rasburicase, ifosfamide, hydroxyurea Antibiotics dapsone, sulfonamides, nitrofurantoin, para‑aminosalicylic acid Antimalarials chloroquine, primaquine Anticonvulsants phenytoin, sodium valproate, phenobarbital Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine 7.6 Potent Inhalation Anesthetics Serious dose-related cardiac arrhythmias may occur if lidocaine solutions containing epinephrine are used in patients during or following the administration of potent inhalation anesthetics [see Warnings and Precautions (5.11) ] .

Lidocaine Hydrochloride + Dapsone⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Digitalis Glycosides⚠️Major

Monitor toxicity when lidocaine is used in patients with digitalis toxicity accompanied by supraventricular arrhythmia and/or atrioventricular block.

Lidocaine Hydrochloride + Epinephrine⚠️Major

Administration of lidocaine with epinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe prolonged hypertension.

Lidocaine Hydrochloride + Flutamide⚠️Major

Lidocaine Hydrochloride + Fluvoxamine⚠️Major

CYP1A2 inhibitor that increases lidocaine plasma AUC by 71% and Cmax by 22%, decreases clearance by 41%-60%, and prolongs half-life by one hour.

Lidocaine Hydrochloride + Hydroxyurea⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Ifosfamide⚠️Major

Lidocaine Hydrochloride + Mepivacaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Metoclopramide⚠️Major

Lidocaine Hydrochloride + Mexiletine⚠️Major

Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with caution.

Lidocaine Hydrochloride + Monoamine Oxidase Inhibitors (Maois)⚠️Major

Administration of lidocaine solutions containing epinephrine may produce severe, prolonged hypertension. Concurrent use should generally be avoided.

Lidocaine Hydrochloride + Nitric Oxide⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Nitrofurantoin⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Nitroglycerin⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Nitroprusside⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Nitrous Oxide⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Nonselective Beta-Adrenergic Antagonists⚠️Major

Administration of lidocaine solutions containing epinephrine may cause severe hypertension and bradycardia. Concurrent use should generally be avoided.

Lidocaine Hydrochloride + Norepinephrine⚠️Major

Administration of lidocaine with norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe prolonged hypertension.

Lidocaine Hydrochloride + Para-Aminosalicyclic Acid⚠️Major

Increased risk of methemoglobinemia when lidocaine hydrochloride is used concurrently with this antibiotic oxidizing agent.

Lidocaine Hydrochloride + Para-Aminosalicylic Acid⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Phenobarbital⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Phenytoin⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Prilocaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Primaquine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Procainamide⚠️Major

Cardiac effects may be additive or antagonistic and toxic effects may be additive when administered with lidocaine.

Lidocaine Hydrochloride + Procaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Quinidine⚠️Major

Cardiac effects may be additive or antagonistic and toxic effects may be additive when administered with lidocaine.

Lidocaine Hydrochloride + Quinine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Rasburicase⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Ropivacaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Sulfasalazine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Tetracaine⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Tocainide⚠️Major

Additive and potentially synergistic toxic effects when used concomitantly with lidocaine hydrochloride. Use with caution.

Lidocaine Hydrochloride + Topical Local Anesthetics⚠️Major

Serious dose-related cardiac arrhythmias may occur if lidocaine solutions containing epinephrine are used during or following administration.

Lidocaine Hydrochloride + Valproate Sodium⚠️Major

Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.

Lidocaine Hydrochloride + Vasopressin⚠️Major

Concurrent administration with ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

Lidocaine Hydrochloride + Butyrophenones🟡Moderate

May reduce or reverse the pressor effect of epinephrine in lidocaine solutions; concurrent use should generally be avoided.

Lidocaine Hydrochloride + Cimetidine🟡Moderate

Concomitant use may reduce hepatic blood flow and lidocaine clearance, increasing incidence of adverse reactions including seizures.

Lidocaine Hydrochloride + Local Anesthetics (Articaine, Benzocaine, Lidocaine, Mepivacaine, Prilocaine, Procaine, Ropivacaine, Tetracaine)🟡Moderate

Toxic effects of local anesthetics are additive. Monitor patients for neurologic and cardiovascular effects related to local anesthetic systemic toxicity.

Lidocaine Hydrochloride + Nitrates🟡Moderate

Patients at increased risk of developing methemoglobinemia when concurrently exposed to nitrates and lidocaine.

Lidocaine Hydrochloride + Nitrites🟡Moderate

Patients at increased risk of developing methemoglobinemia when concurrently exposed to nitrites and lidocaine.

Lidocaine Hydrochloride + Phenothiazines🟡Moderate

May reduce or reverse the pressor effect of epinephrine in lidocaine solutions; concurrent use should generally be avoided.

Lidocaine Hydrochloride + Propofol🟡Moderate

CYP3A4 inhibitor that may increase lidocaine plasma levels by reducing lidocaine clearance.

Lidocaine Hydrochloride + Propranolol🟡Moderate

May increase lidocaine plasma levels by decreasing hepatic blood flow and clearance; also may cause additive cardiac effects.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.