Does Lidocaine Hydrochloride Interact with Cimetidine?
CDI records a moderate classification for Lidocaine Hydrochloride and Cimetidine. The stored summary is: Concomitant use may reduce hepatic blood flow and lidocaine clearance, increasing incidence of adverse reactions including seizures. The mechanism involves reduced hepatic blood flow and lidocaine clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced hepatic blood flow and lidocaine clearance
What To Tell Your Doctor or Pharmacist
If you are taking Lidocaine Hydrochloride and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider