Methylprednisolone Acetate has 21 known drug interactions based on U.S. FDA drug labeling data. 10 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aminoglutethimide, Amphotericin B, Amphotericin B Injection. Patients taking Methylprednisolone Acetate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 21
- Major
- 10
- Moderate
- 11
Major (10)
- Methylprednisolone Acetate + Aminoglutethimide— Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression.
- Methylprednisolone Acetate + Amphotericin B— Concomitant use may cause hypokalemia and has been associated with cardiac enlargement and congestive heart failure.
- Methylprednisolone Acetate + Amphotericin B Injection— Concomitant use with amphotericin B may cause hypokalemia and has been associated with cardiac enlargement and congestiv…
- Methylprednisolone Acetate + Anticholinesterase Agents— Concomitant use may produce severe weakness in patients with myasthenia gravis. Withdraw anticholinesterases 24 hours be…
- Methylprednisolone Acetate + Aspirin— Concomitant use increases risk of gastrointestinal side effects. Aspirin should be used cautiously with corticosteroids …
- Methylprednisolone Acetate + Cyclosporine— Increased activity of both drugs may occur with concurrent use. Convulsions have been reported with this combination.
- Methylprednisolone Acetate + Digitalis Glycosides— Patients may be at risk of arrhythmias due to hypokalemia caused by corticosteroids.
- Methylprednisolone Acetate + Erythromycin— Macrolide antibiotics cause significant decrease in corticosteroid clearance, increasing corticosteroid levels.
- Methylprednisolone Acetate + Ketoconazole— Ketoconazole significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of side effects.
- Methylprednisolone Acetate + Troleandomycin— Macrolide antibiotic inhibits corticosteroid metabolism, increasing plasma concentrations.
Moderate (11)
- Methylprednisolone Acetate + Acidifying Agents— Corticosteroids may increase blood glucose; dosage adjustments of antidiabetic agents may be required.
- Methylprednisolone Acetate + Barbiturates— Barbiturates induce cytochrome P450 3A4 and may enhance corticosteroid metabolism, requiring dosage increase.
- Methylprednisolone Acetate + Carbamazepine— Carbamazepine induces cytochrome P450 3A4 and may enhance corticosteroid metabolism, requiring dosage increase.
- Methylprednisolone Acetate + Cholestyramine Light— Cholestyramine may increase the clearance of corticosteroids.
- Methylprednisolone Acetate + Estrogens— Estrogens may decrease hepatic metabolism of corticosteroids, thereby increasing their effect.
- Methylprednisolone Acetate + Isoniazid— Serum concentrations of isoniazid may be decreased when used with corticosteroids.
- Methylprednisolone Acetate + Macrolide Antibiotics— Macrolide antibiotics cause significant decrease in corticosteroid clearance, increasing corticosteroid effects.
- Methylprednisolone Acetate + Oral Contraceptives— Oral contraceptives may decrease hepatic metabolism of corticosteroids, thereby increasing their effect.
- Methylprednisolone Acetate + Phenytoin— Phenytoin induces cytochrome P450 3A4 and may enhance corticosteroid metabolism, requiring dosage increase.
- Methylprednisolone Acetate + Rifampin— Rifampin induces cytochrome P450 3A4 and may enhance corticosteroid metabolism, requiring dosage increase.
- Methylprednisolone Acetate + Warfarin— Co-administration usually results in inhibition of warfarin response. Coagulation indices should be monitored frequently…