Does Methylprednisolone Acetate Interact with Ketoconazole?
CDI records a major classification for Methylprednisolone Acetate and Ketoconazole. The stored summary is: Ketoconazole significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of side effects. The mechanism involves cytochrome p450 3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Ketoconazole Class
- Azole Antifungal
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Cytochrome P450 3A4 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Methylprednisolone Acetate and your doctor is considering prescribing Ketoconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider