Pirfenidone has 4 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Enoxacin, Fluvoxamine, Ciprofloxacin. Patients taking Pirfenidone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Contraindicated
- 2
- Major
- 2
Contraindicated (2)
- Pirfenidone + Enoxacin— Strong CYP1A2 inhibitor that significantly increases pirfenidone exposure. Should be discontinued prior to pirfenidone a…
- Pirfenidone + Fluvoxamine— Strong CYP1A2 inhibitor that significantly increases pirfenidone exposure. Should be discontinued prior to pirfenidone a…
Major (2)
- Pirfenidone + Ciprofloxacin— Moderate CYP1A2 inhibitor that moderately increases pirfenidone exposure. Dosage reduction recommended if ciprofloxacin …
- Pirfenidone + Nerandomilast— Pirfenidone decreases exposure of nerandomilast and reduces efficacy at 9 mg twice daily dosage. Dosage should be mainta…