Does Pirfenidone Interact with Nerandomilast?
CDI records a major classification for Pirfenidone and Nerandomilast. The stored summary is: Pirfenidone decreases exposure of nerandomilast and reduces efficacy at 9 mg twice daily dosage. Dosage should be maintained at 18 mg twice daily. The mechanism involves pirfenidone decreases nerandomilast exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Pirfenidone Class
- Pyridone
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Pirfenidone decreases nerandomilast exposure
What To Tell Your Doctor or Pharmacist
If you are taking Pirfenidone and your doctor is considering prescribing Nerandomilast (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider