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Naloxegol Oxalate

Also known as: Movantik

Route: Oral

11 interactions on record

Naloxegol Oxalate has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Clarithromycin, Itraconazole, Ketoconazole. Patients taking Naloxegol Oxalate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 11
Contraindicated: 3
Major: 4
Moderate: 2
Minor: 2

Contraindicated (3)

Naloxegol Oxalate + Clarithromycin— Strong CYP3A4 inhibitor that increases plasma naloxegol concentrations and risk of adverse reactions; use is contraindic…
Naloxegol Oxalate + Itraconazole— Strong CYP3A4 inhibitor that increases plasma naloxegol concentrations and risk of adverse reactions; use is contraindic…
Naloxegol Oxalate + Ketoconazole— Strong CYP3A4 inhibitor that increases plasma naloxegol concentrations and risk of adverse reactions; use is contraindic…

Major (4)

Naloxegol Oxalate + Carbamazepine— Strong CYP3A4 inducer that significantly decreases plasma naloxegol concentrations and may decrease efficacy; use is not…
Naloxegol Oxalate + Erythromycin— 7 DRUG INTERACTIONS Moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil) : Increased naloxegol concentr…
Naloxegol Oxalate + Rifampin— Strong CYP3A4 inducer that significantly decreases plasma naloxegol concentrations and may decrease efficacy; concomitan…
Naloxegol Oxalate + St. John'S Wort— Strong CYP3A4 inducer that significantly decreases plasma naloxegol concentrations and may decrease efficacy; use is not…

Moderate (2)

Naloxegol Oxalate + Diltiazem— Moderate CYP3A4 inhibitor that increases naloxegol concentrations; avoid concomitant use or reduce dosage to 12.5 mg onc…
Naloxegol Oxalate + Verapamil— Moderate CYP3A4 inhibitor that increases naloxegol concentrations; avoid concomitant use or reduce dosage to 12.5 mg onc…

Minor (2)

Naloxegol Oxalate + Cimetidine— Weak CYP3A4 inhibitor; clinically significant increases in naloxegol concentrations are not expected and no dosage adjus…
Naloxegol Oxalate + Quinidine— Weak CYP3A4 inhibitor; clinically significant increases in naloxegol concentrations are not expected and no dosage adjus…

Naloxegol Oxalate + Clarithromycin⛔Contraindicated

Strong CYP3A4 inhibitor that increases plasma naloxegol concentrations and risk of adverse reactions; use is contraindicated.

Naloxegol Oxalate + Itraconazole⛔Contraindicated

Strong CYP3A4 inhibitor that increases plasma naloxegol concentrations and risk of adverse reactions; use is contraindicated.

Naloxegol Oxalate + Ketoconazole⛔Contraindicated

Strong CYP3A4 inhibitor that increases plasma naloxegol concentrations and risk of adverse reactions; use is contraindicated.

Naloxegol Oxalate + Carbamazepine⚠️Major

Strong CYP3A4 inducer that significantly decreases plasma naloxegol concentrations and may decrease efficacy; use is not recommended.

Naloxegol Oxalate + Erythromycin⚠️Major

7 DRUG INTERACTIONS Moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil) : Increased naloxegol concentrations; avoid concomitant use; if unavoidable, reduce dosage to 12.5 mg once daily and monitor for adverse reactions. Moderate CYP3A4 inhibitors (e.g., diltiazem, erythromycin, verapamil) Avoid use with moderate CYP3A4 inhibitors; if unavoidable, decrease the dosage of MOVANTIK to 12.5 mg once daily and monitor for adverse reactions [see Dosage and Administration (2.4) ] .

Naloxegol Oxalate + Rifampin⚠️Major

Strong CYP3A4 inducer that significantly decreases plasma naloxegol concentrations and may decrease efficacy; concomitant use is not recommended.

Naloxegol Oxalate + St. John'S Wort⚠️Major

Strong CYP3A4 inducer that significantly decreases plasma naloxegol concentrations and may decrease efficacy; use is not recommended.

Naloxegol Oxalate + Diltiazem🟡Moderate

Moderate CYP3A4 inhibitor that increases naloxegol concentrations; avoid concomitant use or reduce dosage to 12.5 mg once daily and monitor for adverse reactions.

Naloxegol Oxalate + Verapamil🟡Moderate

Moderate CYP3A4 inhibitor that increases naloxegol concentrations; avoid concomitant use or reduce dosage to 12.5 mg once daily and monitor for adverse reactions.

Naloxegol Oxalate + Cimetidine🟢Minor

Weak CYP3A4 inhibitor; clinically significant increases in naloxegol concentrations are not expected and no dosage adjustments are necessary.

Naloxegol Oxalate + Quinidine🟢Minor

Weak CYP3A4 inhibitor; clinically significant increases in naloxegol concentrations are not expected and no dosage adjustments are necessary.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.