Does Naloxegol Oxalate Interact with Cimetidine?
Naloxegol Oxalate and Cimetidine have a minor drug interaction according to U.S. FDA drug labeling data. Weak CYP3A4 inhibitor; clinically significant increases in naloxegol concentrations are not expected and no dosage adjustments are necessary. The mechanism involves cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Cimetidine Class
- Histamine-2 Receptor Antagonist
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Naloxegol Oxalate and Cimetidine occurs because cyp3a4 inhibition. Clinically, this means weak cyp3a4 inhibitor; clinically significant increases in naloxegol concentrations are not expected and no dosage adjustments are necessary. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Naloxegol Oxalate and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider