Adrenalin (Epinephrine) has 16 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 14 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Phenothiazines, Cardiac Glycosides, Dexchlorpheniramine. Patients taking Adrenalin (Epinephrine) should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 16
- Contraindicated
- 1
- Major
- 14
- Moderate
- 1
Contraindicated (1)
- Adrenalin (Epinephrine) + Phenothiazines— Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines; may result in…
Major (14)
- Adrenalin (Epinephrine) + Cardiac Glycosides— Patients receiving cardiac glycosides should be observed carefully for development of cardiac arrhythmias.
- Adrenalin (Epinephrine) + Dexchlorpheniramine— Certain antihistamines, notably dexchlorpheniramine, may potentiate the effects of epinephrine.
- Adrenalin (Epinephrine) + Digitalis Glycosides— Patients receiving digitalis should be observed carefully for development of cardiac arrhythmias.
- Adrenalin (Epinephrine) + Diphenhydramine— Certain antihistamines, notably diphenhydramine, may potentiate the effects of epinephrine.
- Adrenalin (Epinephrine) + Diuretics— Patients receiving diuretics should be observed carefully for development of cardiac arrhythmias.
- Adrenalin (Epinephrine) + Ergot Alkaloids— Ergot alkaloids may reverse the pressor effects of epinephrine.
- Adrenalin (Epinephrine) + Halothane— Coadministration with halogenated hydrocarbon anesthetics may result in arrhythmias; epinephrine should be administered …
- Adrenalin (Epinephrine) + Imipramine— Tricyclic antidepressants may potentiate the effects of epinephrine.
- Adrenalin (Epinephrine) + Levothyroxine Sodium— Levothyroxine sodium may potentiate the effects of epinephrine.
- Adrenalin (Epinephrine) + Monoamine Oxidase Inhibitors (Maois)— MAOIs may potentiate the effects of epinephrine.
- Adrenalin (Epinephrine) + Phentolamine— Alpha-adrenergic blocking drugs antagonize the vasoconstricting and hypertensive effects of epinephrine.
- Adrenalin (Epinephrine) + Propranolol— Beta-adrenergic blocking drugs antagonize the cardiostimulating and bronchodilating effects of epinephrine.
- Adrenalin (Epinephrine) + Quinidine— Patients receiving quinidine should be observed carefully for development of cardiac arrhythmias.
- Adrenalin (Epinephrine) + Tripelennamine— Certain antihistamines, notably tripelannamine, may potentiate the effects of epinephrine.
Moderate (1)
- Adrenalin (Epinephrine) + Acidifying Agents— Possibility of additive effects when epinephrine is administered with other sympathomimetic agents.