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Does Adrenalin Epinephrine Interact with Phenothiazines?

Adrenalin Epinephrine and Phenothiazines have a contraindicated drug interaction according to U.S. FDA drug labeling data. Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines; may result in further lowering of blood pressure. The mechanism involves reversal of epinephrine pressor effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Adrenalin Epinephrine Class
alpha-Adrenergic Agonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Adrenalin Epinephrine and Phenothiazines occurs because reversal of epinephrine pressor effects. Clinically, this means epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines; may result in further lowering of blood pressure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Adrenalin Epinephrine and your doctor is considering prescribing Phenothiazines (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Adrenalin Epinephrine(Adrenalin (Epinephrine))+💊 Phenothiazines

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
alpha-Adrenergic Agonist
Drug B class
—
Source
NLP:adrenalin (epinephrine)

What this means in plain English

Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines; may result in further lowering of blood pressure.

What the FDA label says

"Reversal of epinephrine pressor effects"

📖 Source: NLP:adrenalin (epinephrine)

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.