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Insulin Degludec

Also known as: Tresiba

Insulin Analog

Route: Subcutaneous

Check Insulin Degludec Interactions →

39 interactions on record

Insulin Degludec has 39 known drug interactions based on U.S. FDA drug labeling data. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acidifying Agents, Angiotensin Ii, Disopyramide. Patients taking Insulin Degludec should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 39
Major: 13
Moderate: 24

Major (13)

Insulin Degludec + Acidifying Agents— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Angiotensin Ii— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Disopyramide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Fibrates— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Fluoxetine— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Liraglutide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Macrolide Antibiotics— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Mao Inhibitors— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Monoamine Oxidase Inhibitors (Maois)— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Octreotide— Somatostatin analog may increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be require…
Insulin Degludec + Pentoxifylline— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Pramlintide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
Insulin Degludec + Salicylates— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Moderate (24)

Insulin Degludec + Albuterol— Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring…
Insulin Degludec + Alcohol— May increase or decrease blood glucose lowering effect. Dosage adjustment and increased glucose monitoring may be requir…
Insulin Degludec + Clonidine— May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and incr…
Insulin Degludec + Clozapine— Atypical antipsychotic that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitorin…
Insulin Degludec + Corticosteroids— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Danazol— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Diuretics— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Epinephrine— Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring…
Insulin Degludec + Estrogens— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Glucagon— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Guanethidine— May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.
Insulin Degludec + Isoniazid— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Lithium— May increase or decrease blood glucose lowering effect. Dosage adjustment and increased glucose monitoring may be requir…
Insulin Degludec + Niacin— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Nonselective Beta-Adrenergic Antagonists— May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and incr…
Insulin Degludec + Olanzapine— Atypical antipsychotic that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitorin…
Insulin Degludec + Oral Contraceptives— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Pentamidine— May cause hypoglycemia which may sometimes be followed by hyperglycemia. Dosage adjustment and increased glucose monitor…
Insulin Degludec + Phenothiazines— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Protease Inhibitors— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Reserpine— May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.
Insulin Degludec + Somatropin— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
Insulin Degludec + Terbutaline— Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring…
Insulin Degludec + Thyroid Hormones— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Acidifying Agents⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Angiotensin Ii⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Disopyramide⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Fibrates⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Fluoxetine⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Liraglutide⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Macrolide Antibiotics⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Mao Inhibitors⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Monoamine Oxidase Inhibitors (Maois)⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Octreotide⚠️Major

Somatostatin analog may increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Pentoxifylline⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Pramlintide⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Salicylates⚠️Major

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

Insulin Degludec + Albuterol🟡Moderate

Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Alcohol🟡Moderate

May increase or decrease blood glucose lowering effect. Dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec + Clonidine🟡Moderate

May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec + Clozapine🟡Moderate

Atypical antipsychotic that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Corticosteroids🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Danazol🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Diuretics🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Epinephrine🟡Moderate

Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Estrogens🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Glucagon🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Guanethidine🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.

Insulin Degludec + Isoniazid🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Lithium🟡Moderate

May increase or decrease blood glucose lowering effect. Dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec + Niacin🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Nonselective Beta-Adrenergic Antagonists🟡Moderate

May increase or decrease blood glucose lowering effect and blunt hypoglycemia signs/symptoms. Dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec + Olanzapine🟡Moderate

Atypical antipsychotic that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Oral Contraceptives🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Pentamidine🟡Moderate

May cause hypoglycemia which may sometimes be followed by hyperglycemia. Dosage adjustment and increased glucose monitoring may be required.

Insulin Degludec + Phenothiazines🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Protease Inhibitors🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Reserpine🟡Moderate

May blunt signs and symptoms of hypoglycemia. Increased glucose monitoring may be required.

Insulin Degludec + Somatropin🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Terbutaline🟡Moderate

Sympathomimetic agent that may decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Thyroid Hormones🟡Moderate

May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.

Insulin Degludec + Acetazolamideℹ️Unknown

Table 5: Clinically Significant Drug Interactions with TRESIBA Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors.

Insulin Degludec + Somatostatinℹ️Unknown

Table 5: Clinically Significant Drug Interactions with TRESIBA Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics, GLP-1 receptor agonists, DPP-4 inhibitors, SGLT-2 inhibitors.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.