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Does Insulin Degludec Interact with Macrolide Antibiotics?

Insulin Degludec and Macrolide Antibiotics have a major drug interaction according to U.S. FDA drug labeling data. May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Insulin Degludec Class
Insulin Analog
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Insulin Degludec and your doctor is considering prescribing Macrolide Antibiotics (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Insulin Degludec(Tresiba)+💊 Macrolide Antibiotics(Bactine Antibiotic)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Insulin Analog
Drug B class
—
Source
NLP:insulin degludec

What this means in plain English

May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.

About Insulin Degludec and Macrolide Antibiotics

Insulin Degludec is an Insulin Analog. You may recognize them by the brand names Tresiba and Bactine Antibiotic. Insulin Degludec is given by injection under the skin.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.