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Acitretin

Also known as: Acitretin

Retinoid

Route: Oral

Check Acitretin Interactions →
13 interactions on record⛔ Black Box Warning

Acitretin has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Doxycycline, Iron-Containing Preparations. Patients taking Acitretin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total
13
Contraindicated
8
Major
2
Moderate
2

Contraindicated (8)

  • Acitretin + Alcohol— Concurrent ingestion of acitretin and ethanol can result in formation of etretinate.
  • Acitretin + Doxycycline— Both acitretin and tetracyclines can cause increased intracranial pressure; concurrent use should be avoided.
  • Acitretin + Iron-Containing Preparations— Acitretin interferes with the contraceptive effect of microdosed progestin-only preparations (minipills). These are not …
  • Acitretin + Methotrexate— Combined use of methotrexate and acitretin is contraindicated due to increased risk of hepatitis.
  • Acitretin + Retinoids— Concomitant administration of other oral retinoids with acitretin must be avoided due to risk of hypervitaminosis A.
  • Acitretin + Sarecycline Hydrochloride— Tetracyclines and oral retinoids both may cause increased intracranial pressure. Avoid coadministration.
  • Acitretin + Tetracycline— Combined use of acitretin and tetracyclines is contraindicated because both can cause increased intracranial pressure.
  • Acitretin + Vitamin A— Concomitant administration of vitamin A with acitretin must be avoided due to risk of hypervitaminosis A.

Major (2)

Moderate (2)

  • Acitretin + Glibenclamide— Acitretin treatment potentiated the blood glucose-lowering effect of glyburide in some subjects. Careful supervision of …
  • Acitretin + Phenytoin— Concurrent administration of acitretin with phenytoin may reduce the protein binding of phenytoin.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.