Acitretin has 13 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alcohol, Doxycycline, Iron-Containing Preparations. Patients taking Acitretin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 13
- Contraindicated
- 8
- Major
- 2
- Moderate
- 2
Contraindicated (8)
- Acitretin + Alcohol— Concurrent ingestion of acitretin and ethanol can result in formation of etretinate.
- Acitretin + Doxycycline— Both acitretin and tetracyclines can cause increased intracranial pressure; concurrent use should be avoided.
- Acitretin + Iron-Containing Preparations— Acitretin interferes with the contraceptive effect of microdosed progestin-only preparations (minipills). These are not …
- Acitretin + Methotrexate— Combined use of methotrexate and acitretin is contraindicated due to increased risk of hepatitis.
- Acitretin + Retinoids— Concomitant administration of other oral retinoids with acitretin must be avoided due to risk of hypervitaminosis A.
- Acitretin + Sarecycline Hydrochloride— Tetracyclines and oral retinoids both may cause increased intracranial pressure. Avoid coadministration.
- Acitretin + Tetracycline— Combined use of acitretin and tetracyclines is contraindicated because both can cause increased intracranial pressure.
- Acitretin + Vitamin A— Concomitant administration of vitamin A with acitretin must be avoided due to risk of hypervitaminosis A.
Major (2)
- Acitretin + Microdosed Progestin Minipill— Acitretin interferes with the contraceptive effect of microdosed progestin minipill preparations. Not recommended for co…
- Acitretin + Oral Contraceptives— Acitretin interferes with the contraceptive effect of microdosed progestin preparations. These preparations are not reco…
Moderate (2)
- Acitretin + Glibenclamide— Acitretin treatment potentiated the blood glucose-lowering effect of glyburide in some subjects. Careful supervision of …
- Acitretin + Phenytoin— Concurrent administration of acitretin with phenytoin may reduce the protein binding of phenytoin.