Levoleucovorin Injection has 6 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Fluorouracil, Sulfamethoxazole And Trimethoprim, Phenobarbital. Patients taking Levoleucovorin Injection should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Major
- 2
- Moderate
- 3
Major (2)
- Levoleucovorin Injection + Fluorouracil— Leucovorin products increase toxicity of fluorouracil. Do not initiate or continue therapy if gastrointestinal toxicity …
- Levoleucovorin Injection + Sulfamethoxazole And Trimethoprim— Concomitant use for acute treatment of Pneumocystis jiroveci pneumonia in HIV-infected patients was associated with incr…
Moderate (3)
- Levoleucovorin Injection + Phenobarbital— Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency. Monitor patients taking …
- Levoleucovorin Injection + Phenytoin— Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency. Monitor patients taking …
- Levoleucovorin Injection + Primidone— Folic acid in large amounts may counteract antiepileptic effect and increase seizure frequency. Monitor patients taking …