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Does Sulfamethoxazole And Trimethoprim Interact with Levoleucovorin Injection?

Sulfamethoxazole And Trimethoprim and Levoleucovorin Injection have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use for acute treatment of Pneumocystis jiroveci pneumonia in HIV-infected patients was associated with increased rates of treatment failure and morbidity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Sulfamethoxazole And Trimethoprim Class
Sulfonamide Antimicrobial
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Sulfamethoxazole And Trimethoprim and your doctor is considering prescribing Levoleucovorin Injection (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sulfamethoxazole And Trimethoprim(Bactrim)+💊 Levoleucovorin Injection(Levoleucovorin Calcium)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Sulfonamide Antimicrobial
Drug B class
—
Source
NLP:levoleucovorin injection

What this means in plain English

Concomitant use for acute treatment of Pneumocystis jiroveci pneumonia in HIV-infected patients was associated with increased rates of treatment failure and morbidity.

About Sulfamethoxazole And Trimethoprim and Levoleucovorin Injection

Sulfamethoxazole And Trimethoprim is a Sulfonamide Antimicrobial. Sulfamethoxazole And Trimethoprim is also sold under the brand name Bactrim. Sulfamethoxazole And Trimethoprim is taken by mouth, whereas Levoleucovorin Injection is given by intravenous (IV) infusion.

Recent research & FDA safety updates

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.