Hydantoins

2 interactions on record

Hydantoins has 2 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Levothyroxine Sodium, Liothyronine Sodium. Patients taking Hydantoins should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 2
Moderate: 2

Moderate (2)

Hydantoins + Levothyroxine Sodium— May alter serum T4 and T3 transport or metabolism affecting levothyroxine efficacy.
Hydantoins + Liothyronine Sodium— May cause protein binding site displacement. Phenytoin reduces serum protein binding of thyroid hormones, with total and…

Hydantoins + Levothyroxine Sodium🟡Moderate

May alter serum T4 and T3 transport or metabolism affecting levothyroxine efficacy.

Hydantoins + Liothyronine Sodium🟡Moderate

May cause protein binding site displacement. Phenytoin reduces serum protein binding of thyroid hormones, with total and FT4 reduced 20-40%, but most patients remain clinically euthyroid. Closely monitor thyroid parameters.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.