Does Liothyronine Sodium Interact with Hydantoins?
CDI records a moderate classification for Liothyronine Sodium and Hydantoins. The stored summary is: May cause protein binding site displacement. Phenytoin reduces serum protein binding of thyroid hormones, with total and FT4 reduced 20-40%, but most patients remain clinically euthyroid. Closely monitor thyroid parameters. The mechanism involves reduced serum protein binding of thyroid hormones. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced serum protein binding of thyroid hormones
What To Tell Your Doctor or Pharmacist
If you are taking Liothyronine Sodium and your doctor is considering prescribing Hydantoins (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider