Selexipag has 5 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Gemfibrozil, Clopidogrel, Deferasirox. Patients taking Selexipag should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 5
- Contraindicated
- 1
- Moderate
- 4
Contraindicated (1)
- Selexipag + Gemfibrozil— Strong CYP2C8 inhibitor that doubled selexipag exposure and increased active metabolite exposure approximately 11-fold. …
Moderate (4)
- Selexipag + Clopidogrel— Moderate CYP2C8 inhibitor that increased active metabolite exposure approximately 2.7-fold. Reduce selexipag dosing to o…
- Selexipag + Deferasirox— Moderate CYP2C8 inhibitor that increases exposure to selexipag's active metabolite. Reduce selexipag dosing to once dail…
- Selexipag + Rifampin— CYP2C8 inducer that halved active metabolite exposure. Increase selexipag dose up to twice when co-administered; reduce …
- Selexipag + Teriflunomide— 7 DRUG INTERACTIONS Moderate CYP2C8 inhibitors (e.g., clopidogrel, deferasirox and teriflunomide) increase exposure to t…