Alfuzosin has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 16 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Alfuzosin Hydrochloride, Atazanavir, Atazanavir And Cobicistat. Patients taking Alfuzosin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 16
- Major
- 3
- Moderate
- 1
Contraindicated (16)
- Alfuzosin + Alfuzosin Hydrochloride— 7 DRUG INTERACTIONS Concomitant use of PDE5 inhibitors with alpha adrenergic antagonists, including alfuzosin hydrochlor…
- Alfuzosin + Atazanavir— Other Agents Alpha 1-Adrenoreceptor Antagonist: alfuzosin ↑ alfuzosin Coadministration of REYATAZ with alfuzosin is cont…
- Alfuzosin + Atazanavir And Cobicistat— Other Agents Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Coadministration of EVOTAZ with alfuzosin is contr…
- Alfuzosin + Atazanavir Sulfate— Other Agents Alpha 1-Adrenoreceptor Antagonist: alfuzosin ↑ alfuzosin Coadministration of atazanavir with alfuzosin is c…
- Alfuzosin + Cobicistat— Other Agents: Alpha 1- adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Coadministration with alfuzosin is contraindicat…
- Alfuzosin + Darunavir— Other Agents Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Co-administration is contraindicated due to potent…
- Alfuzosin + Darunavir 600 Mg— Other Agents Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Co-administration is contraindicated due to potent…
- Alfuzosin + Darunavir Ethanolate And Cobicistat— Other agents Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Co-administration is contraindicated due to potent…
- Alfuzosin + Darunavir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide— Table 4: Significant Drug Interactions Concomitant Drug Class: Drug Name Examples Effect on Concentration Clinical Comme…
- Alfuzosin + Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide— Drug Interactions: Alteration in Dose or Regimen May Be Recommended Based on Drug Interaction Studies or Predicted Inter…
- Alfuzosin + Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate— Drug Interactions: Alteration in Dose or Regimen May Be Recommended Based on Drug Interaction Studies or Predicted Inter…
- Alfuzosin + Fosamprenavir Calcium— Other Agents Alpha 1-adrenoreceptor antagonist: Alfuzosin ↑Alfuzosin Coadministration is contraindicated due to potentia…
- Alfuzosin + Lopinavir And Ritonavir— Other Agents Alpha 1-Adrenoreceptor Antagonist: alfuzosin ↑ alfuzosin Contraindicated due to potential hypotension [see …
- Alfuzosin + Nirmatrelvir And Ritonavir— Table 2: Established and Other Potentially Significant Drug Interactions Drug Class Drugs within Class Effect on Concent…
- Alfuzosin + Ritonavir— Other Agents Alpha 1-Adrenoreceptor Antagonist: alfuzosin ↑ alfuzosin Contraindicated due to potential hypotension [see …
- Alfuzosin + Ritonavir 100 Mg— Other Agents Alpha 1-Adrenoreceptor Antagonist: alfuzosin ↑ alfuzosin Contraindicated due to potential hypotension [see …
Major (3)
- Alfuzosin + Itraconazole— Itraconazole increases alfuzosin concentrations, increasing risk of adverse reactions. Not recommended during and 2 week…
- Alfuzosin + Tadalafil— Clinical pharmacology studies conducted with coadministration of tadalafil with alfuzosin. Additive blood-pressure-lower…
- Alfuzosin + Vardenafil— Alpha-blocker interaction with additive blood pressure lowering effects. Clinical pharmacology studies conducted; cautio…
Moderate (1)
- Alfuzosin + Vardenafil Hydrochloride— Caution is advised when vardenafil is co-administered with alfuzosin. Both are vasodilators with blood-pressure-lowering…