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Does Alfuzosin Interact with Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide?

CDI records a contraindicated classification for Alfuzosin and Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide. The stored summary is: Table 4: Significant Drug Interactions Concomitant Drug Class: Drug Name Examples Effect on Concentration Clinical Comment This table is not all inclusive ↑ = increase, ↓ = decrease, ↔ = no effect Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity
Contraindicated
Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide Class
Cytochrome P450 3A Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Alfuzosin and your doctor is considering prescribing Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Alfuzosin(UroXatral)+💊 Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide(Symtuza)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
CDI classifies this record as contraindicated. Confirm the applicable product labeling with your prescriber or pharmacist.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Cytochrome P450 3A Inhibitor
Source
FDA drug label - darunavir, cobicistat, emtricitabine, and tenofovir alafenamide

What this means in plain English

Table 4: Significant Drug Interactions Concomitant Drug Class: Drug Name Examples Effect on Concentration Clinical Comment This table is not all inclusive ↑ = increase, ↓ = decrease, ↔ = no effect Alpha 1-adrenoreceptor antagonist: alfuzosin ↑ alfuzosin Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension.

About Alfuzosin and Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide

Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide is a Cytochrome P450 3A Inhibitor. You may recognize them by the brand names UroXatral and Symtuza. Darunavir Cobicistat Emtricitabine And Tenofovir Alafenamide additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: FDA drug label - darunavir, cobicistat, emtricitabine, and tenofovir alafenamide

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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