Busulfan has 11 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Metronidazole, Bismuth Subcitrate Potassium, Metronidazole And Tetracycline Hydrochloride, Cyclophosphamide. Patients taking Busulfan should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Contraindicated
- 1
- Major
- 6
- Moderate
- 3
- Minor
- 1
Contraindicated (1)
- Busulfan + Metronidazole— Metronidazole increases plasma concentrations of busulfan, resulting in increased risk for serious busulfan toxicity. Sh…
Major (6)
- Busulfan + Bismuth Subcitrate Potassium, Metronidazole And Tetracycline Hydrochloride— Increased busulfan serum concentrations; avoid concomitant use and monitor for busulfan toxicity.
- Busulfan + Cyclophosphamide— Increased incidence of hepatic veno-occlusive disease and mucositis has been reported.
- Busulfan + Cyclophosphamide Injection, Solution— Increased incidence of hepatic veno-occlusive disease and mucositis reported with concomitant use.
- Busulfan + Deferasirox— Deferasirox increases exposure of busulfan. Monitor plasma concentrations and adjust busulfan dose as needed.
- Busulfan + Itraconazole— Reduced busulfan clearance when itraconazole administered concomitantly with high-dose busulfan, increasing risk of busu…
- Busulfan + Thioguanine— Additive myelosuppression and hepatotoxicity risk; portal hypertension and esophageal varices observed with long-term co…
Moderate (3)
- Busulfan + Acetaminophen— Use within 72 hours prior to or concurrent with busulfan may result in reduced busulfan clearance by decreasing glutathi…
- Busulfan + Cytotoxic Agents— Busulfan-induced pulmonary toxicity may be additive to effects of other cytotoxic agents.
- Busulfan + Phenytoin— Increases busulfan clearance by 15% or more, potentially resulting in lower exposure in patients treated with phenytoin …
Minor (1)
- Busulfan + Fluconazole— Has been used with busulfan; decreased clearance of busulfan observed with concomitant use.