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Does Busulfan Interact with Fluconazole?

Busulfan and Fluconazole have a minor drug interaction according to U.S. FDA drug labeling data. Has been used with busulfan; decreased clearance of busulfan observed with concomitant use. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Busulfan Class
Alkylating Drug
Fluconazole Class
Azole Antifungal
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Busulfan and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Busulfan(Myleran)+💊 Fluconazole(Diflucan)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Alkylating Drug
Drug B class
Azole Antifungal
Source
NLP:busulfan

What this means in plain English

Has been used with busulfan; decreased clearance of busulfan observed with concomitant use.

About Busulfan and Fluconazole

Busulfan is an Alkylating Drug, while Fluconazole is an Azole Antifungal. You may recognize them by the brand names Myleran and Diflucan. Both medications are given by intravenous (IV) infusion. Busulfan additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.