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Sedatives

35 interactions on record

Sedatives has 35 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Metoclopramide, Metoclopramide Hydrochloride, Buprenorphine. Patients taking Sedatives should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 35
Contraindicated: 2
Major: 15
Moderate: 18

Contraindicated (2)

Sedatives + Metoclopramide— CNS depressants with increased risk of CNS depression. Avoid concomitant use.
Sedatives + Metoclopramide Hydrochloride— CNS depressants; increased risk of CNS depression. Avoid concomitant use.

Major (15)

Sedatives + Buprenorphine— CNS depressants that increase risk of respiratory depression, profound sedation, coma, and death with concomitant bupren…
Sedatives + Buprenorphine And Naloxone— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Sedatives + Buprenorphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Sedatives + Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Sedatives + Butorphanol Tartrate— CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
Sedatives + Carbinoxamine Maleate— CNS depressants cause additive adverse effects with carbinoxamine. Avoid concomitant use.
Sedatives + Hydrocodone Bitartrate And Acetaminophen— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death; reserve for patients where…
Sedatives + Levorphanol Tartrate— Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.
Sedatives + Methadone Hydrochloride— CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.
Sedatives + Nalbuphine Hydrochloride— Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depress…
Sedatives + Phenobarbital Sodium— Concomitant use of other sedatives with barbiturates may produce additive central nervous system depressant effects.
Sedatives + Promethazine Hydrochloride And Dextromethorphan Hydrobromide— Promethazine may increase, prolong, or intensify sedative action of these agents.
Sedatives + Remifentanil Hydrochloride— CNS depressants increase risk of hypotension, respiratory depression, profound sedation, coma, and death.
Sedatives + Scolopamine Transdermal System— Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, and disorientation.
Sedatives + Scopolamine— Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, or disorientation. Either scopolami…

Moderate (18)

Sedatives + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate— Additive CNS depressant effects when combined with dihydrocodeine; dose reduction of one or both agents recommended.
Sedatives + Apraclonidine— Possibility of additive or potentiating effect with CNS depressants.
Sedatives + Brimonidine— Possibility of additive or potentiating CNS depressant effect with brimonidine.
Sedatives + Brimonidine Tartrate— CNS depressant with potential for additive or potentiating effect when used with brimonidine tartrate ophthalmic solutio…
Sedatives + Brimonidine Tartrate And Timolol Maleate— CNS depressant with possibility of additive or potentiating effect on central nervous system depression.
Sedatives + Brimonidine Tartrate Ophthalmic Solution, 0.15%— CNS depressant; may result in additive or potentiating effect with brimonidine on the central nervous system.
Sedatives + Brinzolamide/Brimonidine Tartrate— Potential additive or potentiating effect with CNS depressants. Specific interaction studies not conducted.
Sedatives + Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide— Antihistamine component has additive CNS depressant effects with sedatives.
Sedatives + Brompheniramine Maleate, Pseudoephedrine Hydrochloride,— Antihistamines have additive effects with sedatives and other CNS depressants.
Sedatives + Brompheniramine, Pseudoephedrine, Dextromethorphan— Antihistamines have additive effects with sedatives and other CNS depressants.
Sedatives + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Sedatives combined with local anesthetic agents may have additive CNS depressant effects. Reduced doses of sedatives are…
Sedatives + Carbachol And Brimonidine Tartrate— Sedatives may result in additive or potentiating CNS depressant effects with YUVEZZI.
Sedatives + Cyproheptadine Hydrochloride— Sedatives may have additive CNS depressant effects with cyproheptadine.
Sedatives + Dantrolene Sodium— Concomitant administration may result in further drowsiness due to CNS depressant effects.
Sedatives + Diazepam— May potentiate or be potentiated by diazepam action. Careful consideration should be given when combining.
Sedatives + Diphenhydramine Hydrochloride— Additive CNS depressant effects with diphenhydramine hydrochloride.
Sedatives + Promethazine Hydrochloride— Promethazine may increase, prolong, or intensify the sedative action of sedatives/hypnotics. Such agents should be avoid…
Sedatives + Ziconotide Acetate— Patients taking concomitant sedatives may be at higher risk of depressed levels of consciousness and increased CNS adver…

Sedatives + Metoclopramide⛔Contraindicated

CNS depressants with increased risk of CNS depression. Avoid concomitant use.

Sedatives + Metoclopramide Hydrochloride⛔Contraindicated

CNS depressants; increased risk of CNS depression. Avoid concomitant use.

Sedatives + Buprenorphine⚠️Major

CNS depressants that increase risk of respiratory depression, profound sedation, coma, and death with concomitant buprenorphine use.

Sedatives + Buprenorphine And Naloxone⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Sedatives + Buprenorphine Hydrochloride⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Sedatives + Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Sedatives + Butorphanol Tartrate⚠️Major

CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.

Sedatives + Carbinoxamine Maleate⚠️Major

CNS depressants cause additive adverse effects with carbinoxamine. Avoid concomitant use.

Sedatives + Hydrocodone Bitartrate And Acetaminophen⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death; reserve for patients where alternatives are inadequate.

Sedatives + Levorphanol Tartrate⚠️Major

Additive CNS depression increasing risk of hypotension, respiratory depression, profound sedation, coma, and death.

Sedatives + Methadone Hydrochloride⚠️Major

CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.

Sedatives + Nalbuphine Hydrochloride⚠️Major

Concomitant use increases risk of respiratory depression, profound sedation, coma, and death due to additive CNS depressant effects.

Sedatives + Phenobarbital Sodium⚠️Major

Concomitant use of other sedatives with barbiturates may produce additive central nervous system depressant effects.

Sedatives + Promethazine Hydrochloride And Dextromethorphan Hydrobromide⚠️Major

Promethazine may increase, prolong, or intensify sedative action of these agents.

Sedatives + Remifentanil Hydrochloride⚠️Major

CNS depressants increase risk of hypotension, respiratory depression, profound sedation, coma, and death.

Sedatives + Scolopamine Transdermal System⚠️Major

Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, and disorientation.

Sedatives + Scopolamine⚠️Major

Concurrent use may potentiate CNS adverse reactions including drowsiness, dizziness, or disorientation. Either scopolamine or the interacting drug should be chosen depending on importance.

Sedatives + Acetaminophen, Caffeine, Dihydrocodeine Bitartrate🟡Moderate

Additive CNS depressant effects when combined with dihydrocodeine; dose reduction of one or both agents recommended.

Sedatives + Apraclonidine🟡Moderate

Possibility of additive or potentiating effect with CNS depressants.

Sedatives + Brimonidine🟡Moderate

Possibility of additive or potentiating CNS depressant effect with brimonidine.

Sedatives + Brimonidine Tartrate🟡Moderate

CNS depressant with potential for additive or potentiating effect when used with brimonidine tartrate ophthalmic solution.

Sedatives + Brimonidine Tartrate And Timolol Maleate🟡Moderate

CNS depressant with possibility of additive or potentiating effect on central nervous system depression.

Sedatives + Brimonidine Tartrate Ophthalmic Solution, 0.15%🟡Moderate

CNS depressant; may result in additive or potentiating effect with brimonidine on the central nervous system.

Sedatives + Brinzolamide/Brimonidine Tartrate🟡Moderate

Potential additive or potentiating effect with CNS depressants. Specific interaction studies not conducted.

Sedatives + Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide🟡Moderate

Antihistamine component has additive CNS depressant effects with sedatives.

Sedatives + Brompheniramine Maleate, Pseudoephedrine Hydrochloride,🟡Moderate

Antihistamines have additive effects with sedatives and other CNS depressants.

Sedatives + Brompheniramine, Pseudoephedrine, Dextromethorphan🟡Moderate

Antihistamines have additive effects with sedatives and other CNS depressants.

Sedatives + Bupivacaine Hydrochloride And Epinephrine Bitartrate🟡Moderate

Sedatives combined with local anesthetic agents may have additive CNS depressant effects. Reduced doses of sedatives are recommended.

Sedatives + Carbachol And Brimonidine Tartrate🟡Moderate

Sedatives may result in additive or potentiating CNS depressant effects with YUVEZZI.

Sedatives + Cyproheptadine Hydrochloride🟡Moderate

Sedatives may have additive CNS depressant effects with cyproheptadine.

Sedatives + Dantrolene Sodium🟡Moderate

Concomitant administration may result in further drowsiness due to CNS depressant effects.

Sedatives + Diazepam🟡Moderate

May potentiate or be potentiated by diazepam action. Careful consideration should be given when combining.

Sedatives + Diphenhydramine Hydrochloride🟡Moderate

Additive CNS depressant effects with diphenhydramine hydrochloride.

Sedatives + Promethazine Hydrochloride🟡Moderate

Promethazine may increase, prolong, or intensify the sedative action of sedatives/hypnotics. Such agents should be avoided or administered in reduced dosage.

Sedatives + Ziconotide Acetate🟡Moderate

Patients taking concomitant sedatives may be at higher risk of depressed levels of consciousness and increased CNS adverse reactions.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.