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Caffeine

Also known as: Pamprin Max Formula, Stanback Headache Powder Reformulated Jan 2011, Capacet, BC Arthritis +34 more

19 interactions on record

Caffeine has 19 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Dipyridamole, Warfarin, Warfarin Sodium. Patients taking Caffeine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 19
Major: 3
Moderate: 15

Major (3)

Caffeine + Dipyridamole— Caffeine may abolish the coronary vasodilation induced by intravenous dipyridamole, potentially leading to false negativ…
Caffeine + Warfarin— CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring
Caffeine + Warfarin Sodium— CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring.

Moderate (15)

Caffeine + Adenosine— Antagonizes the effects of adenosine, potentially reducing efficacy. Larger doses of adenosine may be required.
Caffeine + Ciprofloxacin— Systemic quinolones including ciprofloxacin interfere with the metabolism of caffeine.
Caffeine + Ciprofloxacin Hydrochloride— Systemic quinolones including ciprofloxacin interfere with the metabolism of caffeine.
Caffeine + Clozapine— Moderate or weak CYP1A2 inhibitor that may increase clozapine levels. Monitor patients closely and consider dose reducti…
Caffeine + Deferasirox— Deferasirox inhibits CYP1A2 resulting in increased caffeine concentration. Monitor for exposure related toxicity.
Caffeine + Enasidenib Mesylate— Enasidenib may increase the effect of caffeine in sensitive patients. Consider reducing caffeine intake from food and be…
Caffeine + Migalastat Hydrochloride— Co-administration decreases migalastat AUC and Cmax, which may reduce GALAFOLD efficacy. Avoid co-administration with ca…
Caffeine + Nicotine— Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.
Caffeine + Ofloxacin— Systemic administration of quinolones interferes with the metabolism of caffeine.
Caffeine + Ofloxacin Ophthalmic Solution Usp, 0.3%— Systemic quinolone administration interferes with the metabolism of caffeine.
Caffeine + Regadenoson— Methylxanthine that interferes with the vasodilation activity of regadenoson. Patients should avoid consumption for at l…
Caffeine + Stiripentol— Stiripentol is an inhibitor and inducer of CYP1A2; consider dose adjustment of caffeine when administered concomitantly …
Caffeine + Terbinafine— Terbinafine decreases caffeine clearance by 19%.
Caffeine + Terbinafine Hydrochloride— Terbinafine decreases caffeine clearance by 19%, potentially increasing caffeine exposure.
Caffeine + Terbinafine Tablets 250 Mg— Terbinafine decreases the clearance of caffeine by 19%.

Caffeine + Dipyridamole⚠️Major

Caffeine may abolish the coronary vasodilation induced by intravenous dipyridamole, potentially leading to false negative thallium imaging results.

Caffeine + Warfarin⚠️Major

CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring

Caffeine + Warfarin Sodium⚠️Major

CYP1A2 inhibitor that increases warfarin effect and INR; requires close INR monitoring.

Caffeine + Adenosine🟡Moderate

Antagonizes the effects of adenosine, potentially reducing efficacy. Larger doses of adenosine may be required.

Caffeine + Ciprofloxacin🟡Moderate

Systemic quinolones including ciprofloxacin interfere with the metabolism of caffeine.

Caffeine + Ciprofloxacin Hydrochloride🟡Moderate

Systemic quinolones including ciprofloxacin interfere with the metabolism of caffeine.

Caffeine + Clozapine🟡Moderate

Moderate or weak CYP1A2 inhibitor that may increase clozapine levels. Monitor patients closely and consider dose reduction if necessary.

Caffeine + Deferasirox🟡Moderate

Deferasirox inhibits CYP1A2 resulting in increased caffeine concentration. Monitor for exposure related toxicity.

Caffeine + Enasidenib Mesylate🟡Moderate

Enasidenib may increase the effect of caffeine in sensitive patients. Consider reducing caffeine intake from food and beverages during treatment.

Caffeine + Migalastat Hydrochloride🟡Moderate

Co-administration decreases migalastat AUC and Cmax, which may reduce GALAFOLD efficacy. Avoid co-administration with caffeine at least 2 hours before and 2 hours after taking GALAFOLD.

Caffeine + Nicotine🟡Moderate

Smoking cessation with nicotine replacement may require dose decrease due to deinduction of hepatic enzymes.

Caffeine + Ofloxacin🟡Moderate

Systemic administration of quinolones interferes with the metabolism of caffeine.

Caffeine + Ofloxacin Ophthalmic Solution Usp, 0.3%🟡Moderate

Systemic quinolone administration interferes with the metabolism of caffeine.

Caffeine + Regadenoson🟡Moderate

Methylxanthine that interferes with the vasodilation activity of regadenoson. Patients should avoid consumption for at least 12 hours before regadenoson administration.

Caffeine + Stiripentol🟡Moderate

Stiripentol is an inhibitor and inducer of CYP1A2; consider dose adjustment of caffeine when administered concomitantly with DIACOMIT.

Caffeine + Terbinafine🟡Moderate

Terbinafine decreases caffeine clearance by 19%.

Caffeine + Terbinafine Hydrochloride🟡Moderate

Terbinafine decreases caffeine clearance by 19%, potentially increasing caffeine exposure.

Caffeine + Terbinafine Tablets 250 Mg🟡Moderate

Terbinafine decreases the clearance of caffeine by 19%.

Caffeine + Tipranavirℹ️Unknown

Used as a probe substrate for CYP1A2 activity in phenotypic cocktail study with APTIVUS/ritonavir; no net effect at first dose but moderate induction at steady state.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.