Does Caffeine Interact with Tipranavir?
Caffeine and Tipranavir have a unknown drug interaction according to U.S. FDA drug labeling data. Used as a probe substrate for CYP1A2 activity in phenotypic cocktail study with APTIVUS/ritonavir; no net effect at first dose but moderate induction at steady state. The mechanism involves cyp1a2 induction at steady state. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Tipranavir Class
- Protease Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Caffeine and Tipranavir occurs because cyp1a2 induction at steady state. Clinically, this means used as a probe substrate for cyp1a2 activity in phenotypic cocktail study with aptivus/ritonavir; no net effect at first dose but moderate induction at steady state.
What To Tell Your Doctor or Pharmacist
If you are taking Caffeine and your doctor is considering prescribing Tipranavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider